Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 10/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.43 |
| ▸ | PDE4A | P27815 | 5/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7372973 | 1.00 | PDE4B (0.43) | PDE4BPDE4DPDE4APDE4CALDH1A1 | |
| SCHEMBL7379908 | 1.00 | PDE4B (0.43) | PDE4BPDE4DPDE4APDE4CALDH1A1 | |
| SCHEMBL5362920 | 0.81 | PDE4B (0.56) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL5362912 | 0.81 | PDE4B (0.56) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL7470157 | 0.80 | PDE4B (0.43) | PDE4BPDE4DPDE4APDE4CPDE3A | |
| SCHEMBL7470164 | 0.80 | PDE4B (0.43) | PDE4BPDE4DPDE4APDE4CPDE3A | |
| SCHEMBL14591412 | 0.78 | PDE4B (0.52) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL5351006 | 0.76 | PDE4B (0.55) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL5351001 | 0.76 | PDE4B (0.55) | PDE4BPDE4DPDE4APDE4CPOLB | |
| SCHEMBL5350996 | 0.76 | PDE4B (0.55) | PDE4BPDE4DPDE4APDE4CPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889879-B1 | BUTADIENE DERIVATIVES AND PROCESS FOR PREPARING THEREOF | TANABE SEIYAKU CO (JP) | 2002-06-12 | — | — | EP | disclosed |
| US-6248743-B1 | ANTITHROMBOTIC AGENTS EFFECTIVE TO INHIBIT THE PRODUCTION OF TYPE 1 PLASMINOGEN ACTIVATOR INHIBITOR (PAI-1) | TANABE SEIYAKU CO., LTD. (JP) | 2001-06-19 | — | — | US | disclosed |
| EP-0889879-A1 | BUTADIENE DERIVATIVES AND PROCESS FOR PREPARING THEREOF | TANABE SEIYAKU CO., LTD. (JP) | 1999-01-13 | — | — | EP | disclosed |
| WO-1997036864-A1 | BUTADIENE DERIVATIVES AND PROCESS FOR PREPARING THEREOF | TANABE SEIYAKU CO., LTD. (JP) | 1997-10-09 | — | — | WO | disclosed |