Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.56 |
| ▸ | PDE4A | P27815 | 11/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5362920 | 1.00 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL14591414 | 0.91 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL5351006 | 0.82 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL5351001 | 0.82 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL5350996 | 0.82 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL7366340 | 0.81 | PDE4B (0.56) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL7416129 | 0.81 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL7416126 | 0.81 | PDE4B (0.51) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL7372973 | 0.81 | PDE4B (0.43) | PDE4BPDE4APDE4CPDE4DPOLB | |
| SCHEMBL7379908 | 0.81 | PDE4B (0.43) | PDE4BPDE4APDE4CPDE4DPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169808-B2 | Compounds useful for the preparation of medicaments with phosphodiesterase IV inhibitory activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-01-30 | — | — | US | claimed |
| US-20030195257-A1 | Compounds useful for the preparation of medicaments with phosphodiesterase IV inhibitory activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNTE S.P.A. (IT) | 2003-10-16 | — | — | US | claimed |
| EP-1292563-A2 | COMPOUNDS USEFUL FOR THE PREPARATION OF MEDICAMENTS WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2003-03-19 | — | — | EP | claimed |
| WO-2002000593-A2 | COMPOUNDS USEFUL FOR THE PREPARATION OF MEDICAMENTS WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2002-01-03 | — | — | WO | claimed |
| US-7169808-B2 | Compounds useful for the preparation of medicaments with phosphodiesterase IV inhibitory activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-01-30 | — | — | US | disclosed |
| US-20030195257-A1 | Compounds useful for the preparation of medicaments with phosphodiesterase IV inhibitory activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNTE S.P.A. (IT) | 2003-10-16 | — | — | US | disclosed |
| EP-1292563-A2 | COMPOUNDS USEFUL FOR THE PREPARATION OF MEDICAMENTS WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | Sigma-Tau Industrie Farmaceutiche Riunite S.p.A. (IT) | 2003-03-19 | — | — | EP | disclosed |
| WO-2002000593-A2 | COMPOUNDS USEFUL FOR THE PREPARATION OF MEDICAMENTS WITH PHOSPHODIESTERASE IV INHIBITORY ACTIVITY | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2002-01-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030195257-A1 | Compounds useful for the preparation of medicaments with phosphodiesterase IV inhibitory activity | PDE3A, PDE5A, PDE3B | PDE4B 6/4885PDE4A 5/4885PDE4C 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.