Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 3/20 | 0.57 |
| ▸ | KDM4A | O75164 | 1/20 | 0.51 |
| ▸ | ALPI | P09923 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.49 |
| ▸ | XIAP | P98170 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tyrosine SCHEMBL27680838 | 0.90 | KDM4A (0.64) | SLC7A5KDM4AALPIPKMPTGS1 | |
| SCHEMBL595260 | 0.86 | KDM4A (0.68) | SLC7A5KDM4AALPIPKMPTGS1 | |
| SCHEMBL12209353 | 0.86 | KDM4A (0.68) | SLC7A5KDM4AALPIPKMPTGS1 | |
| SCHEMBL7865835 | 0.85 | KDM4A (0.47) | SLC7A5KDM4AMAOBALDH1A1 | |
| SCHEMBL28393254 | 0.85 | KDM4A (0.47) | SLC7A5KDM4AMAOBALDH1A1 | |
| Hydrochloric Acid SCHEMBL29043595 | 0.85 | KDM4A (0.67) | SLC7A5KDM4AALPIPKMPTGS1 | |
| Hydrochloric Acid SCHEMBL29043597 | 0.85 | KDM4A (0.67) | SLC7A5KDM4AALPIPKMPTGS1 | |
| Hydrochloric Acid SCHEMBL29349718 | 0.85 | KDM4A (0.67) | SLC7A5KDM4AALPIPKMPTGS1 | |
| SCHEMBL29462218 | 0.82 | MAOB (0.47) | KDM4AMAOBALDH1A1 | |
| SCHEMBL4870850 | 0.82 | MAOB (0.47) | KDM4AMAOBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891325-B1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2002-02-06 | — | — | EP | disclosed |
| EP-1157985-A1 | Para- substituted phenylene derivatives and their use as integrin antagonists | G.D. SEARLE & CO. (US) | 2001-11-28 | — | — | EP | disclosed |
| US-5952381-A | SELECTIVELY INHIBITING OR ANTAGONIZING THE INTEGRINS; ANTITUMOR AGENTS, ANTIARTHRITIC AGENTS, VIRICIDES, MICROBIOCIDES; TREATING OSTEOPOROSIS, SKIN DISORDERS | G. D. SEARLE & CO. (US) | 1999-09-14 | — | — | US | disclosed |
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | disclosed |