Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 7/20 | 0.74 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.64 |
| ▸ | MMP2 | P08253 | 1/20 | 0.61 |
| ▸ | MMP7 | P09237 | 1/20 | 0.61 |
| ▸ | MMP9 | P14780 | 1/20 | 0.61 |
| ▸ | MMP12 | P39900 | 1/20 | 0.61 |
| ▸ | MMP13 | P45452 | 1/20 | 0.61 |
| ▸ | ECE1 | P42892 | 1/20 | 0.60 |
| ▸ | MME | P08473 | 3/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
| ▸ | CPA1 | P15085 | 2/20 | 0.56 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10030547 | 1.00 | ACE (0.74) | ACEPSMB5MMP2MMP7MMP9 | |
| SCHEMBL19292528 | 0.90 | ACE (0.70) | ACEPSMB5MMP2MMP7MMP9 | |
| SCHEMBL17996007 | 0.90 | ACE (0.70) | ACEPSMB5MMP2MMP7MMP9 | |
| SCHEMBL21246822 | 0.89 | ACE (0.68) | ACEPSMB5MMP2MMP7MMP9 | |
| SCHEMBL21246823 | 0.89 | ACE (0.68) | ACEPSMB5MMP2MMP7MMP9 | |
| SCHEMBL16330731 | 0.88 | FCER2 (0.63) | ACEPSMB5MMP2MMP7MMP9 | |
| SCHEMBL15730731 | 0.88 | FOLH1 (0.68) | ACEPSMB5MMECPA1ACE2 | |
| SCHEMBL6303137 | 0.87 | PSMB5 (0.67) | ACEPSMB5ECE1MME | |
| SCHEMBL13956887 | 0.86 | PSMB5 (0.67) | ACEPSMB5MMP2MMP7MMP9 | |
| SCHEMBL27418074 | 0.86 | ALDH1A1 (0.64) | ACEPSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | claimed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |