Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 13/20 | 0.47 |
| ▸ | ITGAV | P06756 | 13/20 | 0.47 |
| ▸ | ITGB6 | P18564 | 11/20 | 0.47 |
| ▸ | ITGB1 | P05556 | 6/20 | 0.47 |
| ▸ | ITGA5 | P08648 | 6/20 | 0.47 |
| ▸ | ITGB5 | P18084 | 6/20 | 0.47 |
| ▸ | ITGB8 | P26012 | 6/20 | 0.47 |
| ▸ | ITGA8 | P53708 | 6/20 | 0.47 |
| ▸ | PTGIR | P43119 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.43 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.43 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.43 |
| ▸ | WDR5 | P61964 | 1/20 | 0.42 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.40 |
| ▸ | RHOC | P08134 | 1/20 | 0.40 |
| ▸ | RHOA | P61586 | 1/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7844560 | 0.99 | ITGB3 (0.47) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| Hydrochloric Acid SCHEMBL6224028 | 0.79 | ITGB3 (0.58) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL29448189 | 0.79 | ITGB3 (0.75) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL7501057 | 0.78 | ITGB3 (0.52) | ITGB3ITGAVITGB1ITGB5WDR5 | |
| SCHEMBL7501047 | 0.78 | ITGB3 (0.52) | ITGB3ITGAVITGB1ITGB5WDR5 | |
| SCHEMBL19265544 | 0.78 | ITGB3 (0.63) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL8443562 | 0.77 | ITGB3 (0.51) | ITGB3ITGAVITGB1ITGB5 | |
| SCHEMBL615919 | 0.75 | TACR1 (0.59) | EGLN1RHOCRHOA | |
| SCHEMBL6778283 | 0.75 | ITGB3 (0.64) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL8542414 | 0.74 | PTGIR (0.39) | ITGB3ITGAVITGB6ITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | disclosed |