Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7374470 | 1.00 | MAPT (0.60) | MAPTNPSR1NPC1RAB9AMEN1 | |
| SCHEMBL11013041 | 0.90 | MAPT (0.54) | MAPTNPSR1NPC1RAB9AMEN1 | |
| SCHEMBL11013042 | 0.90 | MAPT (0.54) | MAPTNPSR1NPC1RAB9AMEN1 | |
| SCHEMBL10386660 | 0.86 | MAPT (0.64) | MAPTNPSR1RAB9AMEN1KMT2A | |
| SCHEMBL30553800 | 0.86 | MAPT (0.64) | MAPTNPSR1RAB9AMEN1KMT2A | |
| SCHEMBL7270940 | 0.86 | MAPT (0.64) | MAPTNPSR1RAB9AMEN1KMT2A | |
| SCHEMBL29043783 | 0.86 | MAPT (0.64) | MAPTNPSR1RAB9AMEN1KMT2A | |
| SCHEMBL4608555 | 0.83 | MAPT (0.60) | MAPTNPSR1NPC1RAB9AMEN1 | |
| SCHEMBL4608422 | 0.83 | MAPT (0.60) | MAPTNPSR1NPC1RAB9AMEN1 | |
| SCHEMBL7271101 | 0.83 | MAPT (0.64) | MAPTNPSR1MEN1KMT2AGLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4525478-A | Certain 4-aryl-1,4-dihydro-3,5-pyridinedicarboxylates having vasodilating and anti-hypertensive properties | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-25 | — | — | US | disclosed |
| US-4370334-A | VASODILATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-01-25 | — | — | US | disclosed |
| US-4338322-A | 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1982-07-06 | — | — | US | disclosed |
| US-4284634-A | HYPOTENSIVE VASODILATORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-08-18 | — | — | US | disclosed |
| US-4145432-A | 6-ACYLORYALKYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND A METHOD OF EFFECTING VASODILATION THEREWITH | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1979-03-20 | — | — | US | disclosed |