Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 2/20 | 0.40 |
| ▸ | CASP6 | P55212 | 2/20 | 0.40 |
| ▸ | SENP8 | Q96LD8 | 2/20 | 0.40 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.40 |
| ▸ | SENP6 | Q9GZR1 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 3/20 | 0.40 |
| ▸ | HTR7 | P34969 | 3/20 | 0.40 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.40 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.40 |
| ▸ | RNASEH1 | O60930 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9179481 | 0.85 | HPGD (0.42) | HPGDNOTUMKMT2ATDP1OPRM1 | |
| SCHEMBL949237 | 0.82 | HPGD (0.50) | HPGDNOTUMDDB1CRBNCASP3 | |
| SCHEMBL9036496 | 0.77 | MEN1 (0.44) | HPGDNOTUMKMT2ATDP1GAA | |
| SCHEMBL29765632 | 0.74 | HPGD (0.59) | HPGDNOTUMDDB1CRBNCASP3 | |
| SCHEMBL1464486 | 0.72 | HPGD (0.57) | HPGDNOTUMDDB1CRBNCASP3 | |
| SCHEMBL3641405 | 0.72 | HPGD (0.57) | HPGDNOTUMDDB1CRBNCASP3 | |
| SCHEMBL30642159 | 0.72 | HPGD (0.57) | HPGDNOTUMDDB1CRBNCASP3 | |
| SCHEMBL1462133 | 0.71 | HPGD (0.55) | HPGDNOTUMDDB1CRBNCASP3 | |
| SCHEMBL16767079 | 0.71 | NOTUM (0.56) | HPGDNOTUMDDB1CRBNCASP3 | |
| SCHEMBL6701389 | 0.71 | HPGD (0.55) | HPGDNOTUMDDB1CRBNCASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1995009858-A1 | DIPEPTIDE BORONIC ACID INHIBITORS OF TRYPSIN-LIKE ENZYMES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-04-13 | — | — | WO | claimed |
| US-5462964-A | Administering to treat thrombosis | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-10-31 | — | — | US | disclosed |
| WO-1995009858-A1 | DIPEPTIDE BORONIC ACID INHIBITORS OF TRYPSIN-LIKE ENZYMES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-04-13 | — | — | WO | disclosed |