Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.43 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 8/20 | 0.42 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.42 |
| ▸ | OPRL1 | P41146 | 7/20 | 0.42 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.42 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.42 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11506068 | 0.84 | HPGD (0.38) | HPGDNOTUMOPRM1OPRK1KMT2A | |
| SCHEMBL13727309 | 0.83 | POLB (0.47) | HPGDNOTUMOPRM1OPRK1OPRL1 | |
| SCHEMBL7374608 | 0.82 | HPGD (0.52) | HPGDNOTUMDDB1CRBNOPRM1 | |
| SCHEMBL6473582 | 0.79 | KMT2A (0.53) | HPGDNOTUMCASP3CASP6KMT2A | |
| SCHEMBL9550365 | 0.78 | RNASEH1 (0.56) | HPGDCASP3CASP6KMT2ASENP8 | |
| SCHEMBL6649905 | 0.75 | ALDH1A1 (0.45) | HPGDOPRM1OPRK1KMT2ATDP1 | |
| SCHEMBL30642159 | 0.75 | HPGD (0.57) | HPGDNOTUMDDB1CRBNOPRM1 | |
| SCHEMBL1464486 | 0.75 | HPGD (0.57) | HPGDNOTUMDDB1CRBNOPRM1 | |
| SCHEMBL29765632 | 0.73 | HPGD (0.59) | HPGDNOTUMDDB1CRBNOPRM1 | |
| Water SCHEMBL9309686 | 0.72 | NOTUM (0.55) | HPGDNOTUMDDB1CRBNCHRNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111662566-A | Heptamethine hydroxyindole cyanine dye, and synthesis method and application thereof | 中国科学院宁波材料技术与工程研究所 | 2020-09-15 | — | — | CN | claimed |
| CN-111662566-A | Heptamethine hydroxyindole cyanine dye, and synthesis method and application thereof | 中国科学院宁波材料技术与工程研究所 | 2020-09-15 | — | — | CN | disclosed |
| US-8691864-B2 | Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof | HORIZON THERAPEUTICS USA, INC. (SUCCESSOR IN INTEREST TO RAPTOR PHARMACEUTICAL CORP.) | 2014-04-08 | — | — | US | disclosed |
| US-20120295946-A1 | Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof | National Institute of Health (NIH) | 2012-11-22 | — | — | US | disclosed |
| US-8258172-B2 | Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof | RAPTOR PHARMACEUTICAL CORP (US) | 2012-09-04 | — | — | US | disclosed |
| US-20110021594-A1 | Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof | Raptor Pharmaceutical Corp. | 2011-01-27 | — | — | US | disclosed |
| US-7786162-B2 | Agents useful for reducing amyloid precursor protein and treating dementia and methods of use thereof | Raptor Pharmaceutical Corp. (US) | 2010-08-31 | — | — | US | disclosed |
| US-20090131501-A1 | Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof | TORREYPINES THERAPEUTICS (US) | 2009-05-21 | — | — | US | disclosed |
| EP-1349858-B1 | AGENTS USEFUL FOR REDUCING AMYLOID PRECURSOR PROTEIN AND TREATING DEMANTIA AND METHODS OF USE THEREOF | US GOV HEALTH & HUMAN SERV (US) | 2008-08-27 | — | — | EP | disclosed |
| US-7153882-B2 | Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2006-12-26 | — | — | US | disclosed |
| US-20060270729-A1 | Agents useful for reducing amylioid precursor protein and treating dementia and methods of use thereof | GREIG NIGEL H | 2006-11-30 | — | — | US | disclosed |
| US-20040138282-A1 | Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof | HORIZON THERAPEUTICS USA, INC. (SUCCESSOR IN INTEREST TO RAPTOR PHARMACEUTICAL CORP.) | 2004-07-15 | — | — | US | disclosed |
| EP-1349858-A2 | AGENTS USEFUL FOR REDUCING AMYLOID PRECURSOR PROTEIN AND TREATING DEMANTIA AND METHODS OF USE THEREOF | THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2003-10-08 | — | — | EP | disclosed |
| WO-2002048150-A2 | AGENTS USEFUL FOR REDUCING AMYLOID PRECURSOR PROTEIN AND TREATING DEMANTIA AND METHODS OF USE THEREOF | THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2002-06-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110021594-A1 | Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof | APP, BACE1, PSEN1 | HPGD 657/4885NOTUM 308/4885DDB1 1164/4885 |
| US-20090131501-A1 | Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof | APP, BACE1, PSEN1 | HPGD 657/4885NOTUM 308/4885DDB1 1164/4885 |
| US-20060270729-A1 | Agents useful for reducing amylioid precursor protein and treating dementia and methods of use thereof | IAPP, APP, BACE1 | HPGD 1518/4885NOTUM 349/4885DDB1 1499/4885 |
| US-20120295946-A1 | Agents Useful for Reducing Amyloid Precursor Protein and Treating Dementia and Methods of Use Thereof | APP, BACE1, PSEN1 | HPGD 657/4885NOTUM 308/4885DDB1 1164/4885 |
| US-20040138282-A1 | Agents useful for reducing amyloid precursor protein and treating demantia and methods of use thereof | APP, BACE1, CTH | HPGD 1663/4885NOTUM 423/4885DDB1 583/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.