Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.83 |
| ▸ | HRH1 | P35367 | 1/20 | 0.83 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.82 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.82 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.82 |
| ▸ | TSHR | P16473 | 2/20 | 0.82 |
| ▸ | HTR2C | P28335 | 2/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.82 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.61 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.61 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.59 |
| ▸ | CCR3 | P51677 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | HTR7 | P34969 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6057184 | 0.96 | HTR2A (0.84) | HTR2AHRH1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9375973 | 0.91 | HTR2A (1.00) | HTR2AHRH1CYP1A2CYP3A4CYP2D6 | |
| Glemanserin SCHEMBL120012 | 0.90 | HTR2A (1.00) | HTR2AHRH1CYP1A2CYP3A4CYP2D6 | |
| Glemanserin SCHEMBL7838106 | 0.89 | HTR2A (0.97) | HTR2AHRH1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL6057448 | 0.84 | HTR2A (0.65) | HTR2AHRH1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9328976 | 0.82 | HTR2A (0.84) | HTR2AHRH1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL10340052 | 0.81 | HRH1 (0.84) | HTR2AHRH1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9330147 | 0.81 | HTR2A (0.87) | HTR2ACYP1A2CYP3A4CYP2D6TSHR | |
| SCHEMBL9328969 | 0.81 | HTR2A (0.82) | HTR2AHRH1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9179569 | 0.81 | HTR2A (0.82) | HTR2AHRH1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0714292-A4 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | CAMBRIDGE NEUROSCIENCE INC (US) | 1996-10-09 | — | — | EP | claimed |
| EP-0714292-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | CAMBRIDGE NEUROSCIENCE, INC. (US) | 1996-06-05 | — | — | EP | claimed |
| WO-1995000131-A1 | SIGMA RECEPTOR LIGANDS AND THE USE THEREOF | CAMBRIDGE NEUROSCIENCE, INCORPORATED (US) | 1995-01-05 | — | — | WO | claimed |
| EP-0325063-B1 | Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia | MERRELL DOW PHARMA (US) | 1994-03-09 | — | — | EP | claimed |
| US-4908369-A | Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-13 | — | — | US | claimed |
| EP-0337136-A2 | Piperidine derivatives in the treatment of extrapyramidal side effects associated with neuroleptic therapy | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-10-18 | — | — | EP | claimed |
| EP-0319962-A2 | Piperidinyl methanol derivatives for the treatment of anxiety | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-06-14 | — | — | EP | claimed |
| EP-0325063-B1 | Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia | MERRELL DOW PHARMA (US) | 1994-03-09 | — | — | EP | disclosed |
| US-5169096-A | Serotonin antagonists, analgesics | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-12-08 | — | — | US | disclosed |
| US-5106855-A | Method for the treatment of glaucoma | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-04-21 | — | — | US | disclosed |
| EP-0434021-A2 | 4-Piperidine methanol derivatives for the treatment of glaucoma | MERRELL PHARMACEUTICALS INC. (US) | 1991-06-26 | — | — | EP | disclosed |
| US-5021428-A | Novel chemical compounds for the prophylactic treatment of migraine | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-06-04 | — | — | US | disclosed |
| US-4908369-A | Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-03-13 | — | — | US | disclosed |
| EP-0208235-B1 | N-ARALKYL PIPERIDINEMETHANOL DERIVATIVES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1990-01-10 | — | — | EP | disclosed |
| EP-0337136-A2 | Piperidine derivatives in the treatment of extrapyramidal side effects associated with neuroleptic therapy | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-10-18 | — | — | EP | disclosed |
| EP-0325063-A1 | Use of 1,4-disubstituted-piperidinyl compounds in the manufacture of a medicament for the treatment of insomnia | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-07-26 | — | — | EP | disclosed |
| EP-0319962-A2 | Piperidinyl methanol derivatives for the treatment of anxiety | MERRELL DOW PHARMACEUTICALS INC. (US) | 1989-06-14 | — | — | EP | disclosed |
| US-4783471-A | N-aralkyl piperidine methanol derivatives and the uses thereof | MERRELL DOW PHARMACEUTICALS INC. (US) | 1988-11-08 | — | — | US | disclosed |