Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 7/20 | 1.00 |
| ▸ | HTR2C | P28335 | 3/20 | 0.73 |
| ▸ | HTR7 | P34969 | 2/20 | 0.73 |
| ▸ | HRH1 | P35367 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.68 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.68 |
| ▸ | HTR6 | P50406 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9330147 | 0.91 | HTR2A (0.87) | HTR2AHTR2CHTR7CYP2D6KDM4E | |
| SCHEMBL7375182 | 0.91 | HTR2A (0.83) | HTR2AHTR2CHTR7HRH1CYP2D6 | |
| SCHEMBL6057184 | 0.87 | HTR2A (0.84) | HTR2AHTR2CHTR7HRH1CYP2D6 | |
| SCHEMBL9328582 | 0.86 | HTR2A (0.87) | HTR2AHTR2CHTR7HRH1CYP2D6 | |
| Glemanserin SCHEMBL120012 | 0.82 | HTR2A (1.00) | HTR2AHTR2CHTR7HRH1CYP2D6 | |
| Hydrochloric Acid SCHEMBL7411439 | 0.81 | HTR2A (0.67) | HTR2ACYP2D6KDM4ECYP1A2CYP3A4 | |
| Glemanserin SCHEMBL7838106 | 0.80 | HTR2A (0.97) | HTR2AHTR2CHTR7HRH1CYP2D6 | |
| SCHEMBL9328976 | 0.80 | HTR2A (0.84) | HTR2AHTR2CHTR7HRH1CYP2D6 | |
| SCHEMBL9179569 | 0.79 | HTR2A (0.82) | HTR2AHTR2CHTR7HRH1CYP2D6 | |
| SCHEMBL9328969 | 0.79 | HTR2A (0.82) | HTR2AHTR2CHTR7HRH1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0294183-B1 | Use of ethylamine derivatives as antihypertensive agents | AJINOMOTO KK (JP) | 1994-03-30 | — | — | EP | claimed |
| EP-0294183-A1 | Use of ethylamine derivatives as antihypertensive agents | AJINOMOTO CO., INC. (JP) | 1988-12-07 | — | — | EP | claimed |
| EP-0294183-B1 | Use of ethylamine derivatives as antihypertensive agents | AJINOMOTO KK (JP) | 1994-03-30 | — | — | EP | disclosed |
| US-5231105-A | Ethylamine derivatives and antihypertensives containing the same | AJINOMOTO CO., INC. (JP) | 1993-07-27 | — | — | US | disclosed |
| EP-0294183-A1 | Use of ethylamine derivatives as antihypertensive agents | AJINOMOTO CO., INC. (JP) | 1988-12-07 | — | — | EP | disclosed |