Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7384054 | 0.96 | GRIN2B (0.42) | NAMPTGRIN2BHDAC1TDP1MEN1 | |
| SCHEMBL7375395 | 0.93 | NAMPT (0.43) | NAMPTGRIN2BHDAC1TDP1MEN1 | |
| SCHEMBL7384394 | 0.89 | NAMPT (0.42) | NAMPTGRIN2BHDAC1TDP1MKNK2 | |
| SCHEMBL6058751 | 0.86 | NAMPT (0.44) | NAMPTGRIN2BHDAC1MKNK2KDM4E | |
| SCHEMBL6059170 | 0.84 | NAMPT (0.43) | NAMPTGRIN2BHDAC1MKNK2KDM4E | |
| SCHEMBL7377629 | 0.83 | TDP1 (0.41) | GRIN2BTDP1MEN1KMT2AMAPK1 | |
| SCHEMBL7379372 | 0.82 | NAMPT (0.41) | NAMPTGRIN2BHDAC1MKNK2MAPK1 | |
| SCHEMBL6059029 | 0.80 | NAMPT (0.40) | NAMPTGRIN2BHDAC1MKNK2KDM4E | |
| SCHEMBL7382508 | 0.80 | TDP1 (0.39) | GRIN2BTDP1MEN1KMT2AMAPK1 | |
| SCHEMBL2871142 | 0.79 | NAMPT (0.46) | NAMPTGRIN2BHDAC1MKNK2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1180098-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2002-02-20 | — | — | EP | disclosed |
| WO-2000066557-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2000-11-09 | — | — | WO | disclosed |