Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
| ▸ | CTSK | P43235 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.36 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | BCL2 | P10415 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.35 |
| ▸ | NPR3 | P17342 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7375395 | 0.96 | NAMPT (0.43) | NAMPTGRIN2BHDAC1MKNK2CTSS | |
| SCHEMBL7384054 | 0.94 | GRIN2B (0.42) | NAMPTGRIN2BHDAC1MKNK2PPARG | |
| SCHEMBL7375295 | 0.89 | NAMPT (0.42) | NAMPTGRIN2BHDAC1MKNK2KDM4E | |
| SCHEMBL6059170 | 0.89 | NAMPT (0.43) | NAMPTGRIN2BHDAC1MKNK2PPARG | |
| SCHEMBL6058751 | 0.86 | NAMPT (0.44) | NAMPTGRIN2BHDAC1MKNK2PPARG | |
| SCHEMBL6059029 | 0.84 | NAMPT (0.40) | NAMPTGRIN2BHDAC1MKNK2PPARG | |
| SCHEMBL7379372 | 0.82 | NAMPT (0.41) | NAMPTGRIN2BHDAC1MKNK2PPARG | |
| SCHEMBL5076532 | 0.81 | NAMPT (0.47) | NAMPTGRIN2BHDAC1PPARGPPARA | |
| SCHEMBL5076560 | 0.81 | GRIN2B (0.42) | NAMPTGRIN2BHDAC1CTSSCTSK | |
| SCHEMBL7260124 | 0.80 | NAMPT (0.44) | NAMPTGRIN2BHDAC1MKNK2PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1180098-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2002-02-20 | — | — | EP | disclosed |
| WO-2000066557-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2000-11-09 | — | — | WO | disclosed |