Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 3/20 | 0.67 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.67 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.67 |
| ▸ | CACNA1C | Q13936 | 3/20 | 0.67 |
| ▸ | HTR1A | P08908 | 2/20 | 0.67 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.67 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.67 |
| ▸ | DRD1 | P21728 | 2/20 | 0.67 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.67 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.67 |
| ▸ | DRD3 | P35462 | 2/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.67 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.67 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.67 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.67 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.67 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.67 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.67 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.67 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7377868 | 0.90 | TBXA2R (0.67) | TBXA2RADRA1ASLC6A3CACNA1CHTR1A | |
| SCHEMBL10877640 | 0.90 | TBXA2R (0.70) | TBXA2RADRA1ASLC6A3CACNA1CHTR1A | |
| SCHEMBL3017208 | 0.90 | CYP2C9 (0.73) | TBXA2RADRA1ASLC6A3CACNA1CHTR1A | |
| SCHEMBL11732148 | 0.88 | TBXA2R (0.77) | TBXA2RADRA1ASLC6A3CACNA1CHTR1A | |
| SCHEMBL7376242 | 0.87 | TBXA2R (0.70) | TBXA2RADRA1ASLC6A3CACNA1CHTR1A | |
| SCHEMBL4542680 | 0.86 | TBXA2R (0.74) | TBXA2RADRA1ASLC6A3CACNA1CHTR1A | |
| SCHEMBL11523639 | 0.86 | CYP2C9 (0.65) | TBXA2RADRA1ASLC6A3CACNA1CHTR1A | |
| SCHEMBL7273568 | 0.85 | CYP2C9 (0.67) | TBXA2RADRA1ASLC6A3CACNA1CHTR1A | |
| SCHEMBL11773884 | 0.85 | TSHR (0.65) | TBXA2RADRA1ASLC6A3CACNA1CHTR1A | |
| SCHEMBL3031020 | 0.85 | ADORA3 (0.82) | TBXA2RADRA1ASLC6A3CACNA1CHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4525478-A | Certain 4-aryl-1,4-dihydro-3,5-pyridinedicarboxylates having vasodilating and anti-hypertensive properties | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-25 | — | — | US | disclosed |
| US-4370334-A | VASODILATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-01-25 | — | — | US | disclosed |
| US-4338322-A | 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1982-07-06 | — | — | US | disclosed |
| US-4284634-A | HYPOTENSIVE VASODILATORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-08-18 | — | — | US | disclosed |
| US-4145432-A | 6-ACYLORYALKYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND A METHOD OF EFFECTING VASODILATION THEREWITH | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1979-03-20 | — | — | US | disclosed |