Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tropisetron. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A known ✓ | P46098 | 9/20 | 0.98 |
| ▸ | HTR3E known ✓ | A5X5Y0 | 7/20 | 0.98 |
| ▸ | HTR3B known ✓ | O95264 | 7/20 | 0.98 |
| ▸ | HTR3D known ✓ | Q70Z44 | 7/20 | 0.98 |
| ▸ | HTR3C known ✓ | Q8WXA8 | 7/20 | 0.98 |
| ▸ | APEX1 | P27695 | 2/20 | 1.00 |
| ▸ | RECQL | P46063 | 1/20 | 1.00 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.98 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.98 |
| ▸ | CHRNA1 | P02708 | 2/20 | 0.98 |
| ▸ | CHRNG | P07510 | 2/20 | 0.98 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.98 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.98 |
| ▸ | CHRNB1 | P11230 | 2/20 | 0.98 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.98 |
| ▸ | CHRNA3 | P32297 | 2/20 | 0.98 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.98 |
| ▸ | CHRND | Q07001 | 2/20 | 0.98 |
| ▸ | MAPT | P10636 | 2/20 | 0.98 |
| ▸ | LMNA | P02545 | 2/20 | 0.98 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tropisetron SCHEMBL133873 | 1.00 | APEX1 (1.00) | APEX1RECQLHTR3AHTR3EHTR3B | |
| Tropisetron SCHEMBL6273985 | 1.00 | APEX1 (1.00) | APEX1RECQLHTR3AHTR3EHTR3B | |
| Tropisetron SCHEMBL669358 | 1.00 | APEX1 (1.00) | APEX1RECQLHTR3AHTR3EHTR3B | |
| Tropisetron SCHEMBL28012530 | 0.99 | APEX1 (0.98) | APEX1RECQLHTR3AHTR3EHTR3B | |
| Tropisetron SCHEMBL463128 | 0.99 | HTR3A (1.00) | APEX1RECQLHTR3AHTR3EHTR3B | |
| Tropisetron SCHEMBL17766649 | 0.99 | HTR3A (1.00) | APEX1RECQLHTR3AHTR3EHTR3B | |
| Tropisetron SCHEMBL31061471 | 0.99 | HTR3A (1.00) | APEX1RECQLHTR3AHTR3EHTR3B | |
| Tropisetron SCHEMBL29930627 | 0.99 | HTR3A (1.00) | APEX1RECQLHTR3AHTR3EHTR3B | |
| Tropisetron SCHEMBL18297 | 0.99 | HTR3A (1.00) | APEX1RECQLHTR3AHTR3EHTR3B | |
| Tropisetron SCHEMBL29405651 | 0.99 | HTR3A (1.00) | APEX1RECQLHTR3AHTR3EHTR3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002036113-A1 | COMPOSITION COMPRISING: SEROTONIN RECEPTOR ANTAGONISTS (5HT-2, 5HT-3) AND AGONIST (5HT-4) | RESPIRATORIUS AB (SE) | 2002-05-10 | — | — | WO | disclosed |
| WO-2002036114-A1 | COMPOSITION COMPRISING SEROTONIN RECEPTOR ANTAGONISTS, 5 HT-2 AND 5 HT-3 | RESPIRATORIUS AB (SE) | 2002-05-10 | — | — | WO | disclosed |
| WO-2001095902-A1 | A COMPOSITION COMPRISING A COMBINATION OF RECEPTOR AGONISTS AND ANTAGONISTS | RESPIRATORIUS AB (SE) | 2001-12-20 | — | — | WO | disclosed |
| WO-2001095903-A1 | 5-HT3 RECEPTOR ANTAGONISTS FOR TREATMENT OF DISORDERS INVOLVING AIRWAY CONSTRICTION | RESPIRATORIUS AB (SE) | 2001-12-20 | — | — | WO | disclosed |