Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRP | O00591 | 8/20 | 0.72 |
| ▸ | GABRD | O14764 | 8/20 | 0.72 |
| ▸ | GABRA1 | P14867 | 8/20 | 0.72 |
| ▸ | GABRB1 | P18505 | 8/20 | 0.72 |
| ▸ | GABRG2 | P18507 | 8/20 | 0.72 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.72 |
| ▸ | GABRA5 | P31644 | 8/20 | 0.72 |
| ▸ | GABRA3 | P34903 | 8/20 | 0.72 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.72 |
| ▸ | GABRB2 | P47870 | 8/20 | 0.72 |
| ▸ | GABRA4 | P48169 | 8/20 | 0.72 |
| ▸ | GABRE | P78334 | 8/20 | 0.72 |
| ▸ | GABRA6 | Q16445 | 8/20 | 0.72 |
| ▸ | GABRG1 | Q8N1C3 | 8/20 | 0.72 |
| ▸ | GABRG3 | Q99928 | 8/20 | 0.72 |
| ▸ | GABRQ | Q9UN88 | 8/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369808 | 0.87 | GABRP (0.67) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7377486 | 0.87 | GABRP (0.67) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7410806 | 0.85 | GABRP (0.64) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7378264 | 0.84 | GABRP (1.00) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7375618 | 0.82 | GABRP (0.74) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7374983 | 0.81 | GABRP (0.72) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL23000896 | 0.79 | GABRP (0.70) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7374398 | 0.79 | GABRP (0.51) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7368520 | 0.79 | GABRP (0.58) | GABRPGABRDGABRA1GABRB1GABRG2 | |
| SCHEMBL7373665 | 0.78 | GABRP (0.68) | GABRPGABRDGABRA1GABRB1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688809-A | 5-heteroarylindole derivatives | PFIZER INC. (US) | 1997-11-18 | — | — | US | disclosed |
| EP-0743942-A1 | 5-HETEROARYLINDOLE DERIVATIVES AS BENZODIAZEPINE RECEPTOR SITE AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995021836-A1 | 5-HETEROARYLINDOLE DERIVATIVES AS BENZODIAZEPINE RECEPTOR SITE AGONISTS AND ANTAGONISTS | PFIZER INC. (US) | 1995-08-17 | — | — | WO | disclosed |