Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 13/20 | 0.53 |
| ▸ | PDE4A | P27815 | 12/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5350500 | 1.00 | PDE4B (0.53) | PDE4BPDE4APDE4DPDE4CPOLB | |
| SCHEMBL7332295 | 0.89 | PDE4B (0.53) | PDE4BPDE4APDE4DPDE4CPOLB | |
| SCHEMBL7328806 | 0.89 | PDE4B (0.53) | PDE4BPDE4APDE4DPDE4CPOLB | |
| SCHEMBL7326065 | 0.85 | RECQL (0.51) | PDE4BPDE4APDE4DPDE4CPOLB | |
| SCHEMBL7326058 | 0.85 | RECQL (0.51) | PDE4BPDE4APDE4DPDE4CPOLB | |
| SCHEMBL27919546 | 0.84 | ALDH1A1 (0.61) | POLB | |
| SCHEMBL7375826 | 0.83 | PDE4B (0.57) | PDE4BPDE4APDE4DPDE4CPOLB | |
| SCHEMBL7361212 | 0.82 | RECQL (0.51) | PDE4BPDE4APDE4DPDE4CPOLB | |
| SCHEMBL7325727 | 0.82 | RECQL (0.51) | PDE4BPDE4APDE4DPDE4C | |
| SCHEMBL2371289 | 0.81 | PDE4B (0.60) | PDE4BPDE4APDE4DPDE4CPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7169808-B2 | Compounds useful for the preparation of medicaments with phosphodiesterase IV inhibitory activity | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2007-01-30 | — | — | US | claimed |