Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.61 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.61 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.61 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.61 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7317640 | 0.85 | MAPK8 (0.75) | MAPK8HPGDKMT2A | |
| SCHEMBL7369941 | 0.84 | MAPK8 (0.53) | PDE4APDE4BPDE4CPDE4DMAPK8 | |
| SCHEMBL7370564 | 0.84 | MAPK8 (0.58) | PDE4APDE4BPDE4CPDE4DMAPK8 | |
| SCHEMBL7367147 | 0.84 | MAPK8 (0.55) | PDE4APDE4BPDE4CPDE4DMAPK8 | |
| SCHEMBL7372569 | 0.82 | MAPK8 (0.56) | PDE4APDE4BPDE4CPDE4DMAPK8 | |
| SCHEMBL7365751 | 0.82 | MAPK8 (0.67) | MAPK8KMT2A | |
| SCHEMBL7368139 | 0.82 | MAPK8 (0.58) | PDE4APDE4BPDE4CPDE4DMAPK8 | |
| SCHEMBL7368205 | 0.81 | MAPK8 (0.54) | PDE4APDE4BPDE4CPDE4DMAPK8 | |
| SCHEMBL7365941 | 0.81 | HPGD (0.60) | MAPK8HPGDKMT2AGAA | |
| SCHEMBL7369712 | 0.81 | MAPK8 (0.59) | MAPK8KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6380218-B1 | FOR THERAPY OF RESPIRATORY, ALLERGIC, AND INFLAMMATORY DISORDERS COMPRISING ASTHMA, CHRONIC OBSTRUCTIVE PULMONARY DISEASE, ACUTE RESPIRATORY DISEASE SYNDROME, PULMONARY HYPERSENSITIVITY, AND ALLERGIC RHINITIS IN A MAMMAL | PFIZER INC | 2002-04-30 | — | — | US | disclosed |
| EP-0971894-A1 | NICOTINAMIDE DERIVATIVES | Pfizer Products Inc. (US) | 2000-01-19 | — | — | EP | disclosed |
| WO-1998045268-A1 | NICOTINAMIDE DERIVATIVES | PFIZER PRODUCTS INC. (US) | 1998-10-15 | — | — | WO | disclosed |