Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 1/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | PTGER4 | P35408 | 2/20 | 0.62 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7371983 | 0.95 | MAPK8 (0.69) | MAPK8KMT2APTGER4LMNAHPGD | |
| SCHEMBL7168843 | 0.95 | MAPK8 (0.72) | MAPK8KMT2APTGER4 | |
| SCHEMBL7363675 | 0.94 | MAPK8 (0.67) | MAPK8KMT2APTGER4LMNAHPGD | |
| SCHEMBL7371446 | 0.94 | LMNA (0.72) | MAPK8KMT2ALMNAHPGDSMN1; SMN2 | |
| SCHEMBL4087178 | 0.93 | MAPK8 (0.69) | MAPK8KMT2APTGER4LMNAHPGD | |
| Hydrochloric Acid SCHEMBL6904217 | 0.93 | MAPK8 (0.66) | MAPK8KMT2APTGER4LMNAHPGD | |
| SCHEMBL7368852 | 0.92 | MAPK8 (0.65) | MAPK8PTGER4LMNAHPGDSMN1; SMN2 | |
| SCHEMBL7365751 | 0.92 | MAPK8 (0.67) | MAPK8KMT2APTGER4 | |
| SCHEMBL4086210 | 0.91 | MAPK8 (0.64) | MAPK8KMT2APTGER4LMNAHPGD | |
| SCHEMBL4081701 | 0.91 | MAPK8 (0.64) | MAPK8KMT2APTGER4LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0357316-B1 | ANTIDEPRESSANT N-SUBSTITUTED NICOTINAMIDE COMPOUNDS | PFIZER INC. (US) | 1993-04-14 | — | — | EP | disclosed |
| EP-0357316-A1 | Antidepressant N-substituted nicotinamide compounds | PFIZER INC. (US) | 1990-03-07 | — | — | EP | disclosed |
| US-4861891-A | Antidepressant N-substituted nicotinamide compounds | PFIZER INC. (US) | 1989-08-29 | — | — | US | disclosed |