Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MC4R | P32245 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16311742 | 0.92 | ALDH1A1 (0.52) | ALDH1A1KDM4EMAPTHTTBLM | |
| SCHEMBL491245 | 0.80 | ALDH1A1 (0.54) | MC4RALDH1A1KDM4EMAPTHTT | |
| SCHEMBL12708630 | 0.80 | ALDH1A1 (0.48) | ALDH1A1KDM4EMAPTHTTBLM | |
| SCHEMBL12877532 | 0.79 | ALDH1A1 (0.52) | MC4RALDH1A1KDM4EMAPTHTT | |
| SCHEMBL16311762 | 0.77 | ALDH1A1 (0.45) | ALDH1A1KDM4EMAPTHTTBLM | |
| SCHEMBL16311763 | 0.77 | ALDH1A1 (0.48) | ALDH1A1KDM4EMAPTHTTBLM | |
| SCHEMBL491199 | 0.77 | ALDH1A1 (0.56) | MC4RALDH1A1KDM4EMAPTHTT | |
| SCHEMBL14307503 | 0.76 | ALDH1A1 (0.50) | MC4RALDH1A1KDM4EMAPTHTT | |
| SCHEMBL12221880 | 0.76 | MAPT (0.47) | MC4RALDH1A1KDM4EMAPTHTT | |
| SCHEMBL491248 | 0.75 | ALDH1A1 (0.46) | MC4RALDH1A1KDM4EMAPTHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5166341-A | Selective antagonist of serotonin 3(5-HT3) receptor | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1992-11-24 | — | — | US | disclosed |
| US-5017573-A | Serotonin receptor antagonist | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1991-05-21 | — | — | US | disclosed |
| EP-0358903-A2 | Indazole-3-carboxylic acid derivatives | DAINIPPON PHARMACEUTICAL CO., LTD. (JP) | 1990-03-21 | — | — | EP | disclosed |