Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 5/20 | 0.62 |
| ▸ | DRD3 | P35462 | 5/20 | 0.62 |
| ▸ | HTR1A | P08908 | 6/20 | 0.56 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7343645 | 0.98 | DRD2 (0.61) | DRD2DRD3HTR1APARP1HTR3A | |
| SCHEMBL3222580 | 0.77 | DRD2 (1.00) | DRD2DRD3HTR1APARP1SLC6A2 | |
| SCHEMBL7343813 | 0.77 | DRD2 (1.00) | DRD2DRD3HTR1APARP1SLC6A2 | |
| SCHEMBL6483129 | 0.77 | DRD2 (1.00) | DRD2DRD3HTR1APARP1SLC6A2 | |
| SCHEMBL9204124 | 0.76 | DRD2 (0.57) | DRD2DRD3HTR1APARP1HTR3A | |
| SCHEMBL9124998 | 0.75 | DRD2 (0.56) | DRD2DRD3HTR1APARP1HTR3A | |
| Hydrochloric Acid SCHEMBL7343783 | 0.74 | DRD2 (0.39) | DRD2DRD3HTR1A | |
| SCHEMBL7348495 | 0.74 | DRD2 (0.58) | DRD2DRD3HTR1APARP1HTR3A | |
| SCHEMBL7354359 | 0.73 | DRD2 (0.53) | DRD2DRD3HTR1APARP1HTR3A | |
| SCHEMBL7342743 | 0.73 | DRD2 (0.53) | DRD2DRD3HTR1APARP1HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5436240-A | Schizophrenia, Parkinson's disease, depression or hypotensive agents using tricyclic amines | THE UPJOHN COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0480939-B1 | HETEROCYCLIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | UPJOHN CO (US) | 1995-01-25 | — | — | EP | disclosed |
| US-5273975-A | Heterocyclic amines having central nervous system activity | THE UPJOHN COMPANY (US) | 1993-12-28 | — | — | US | disclosed |
| WO-1990015058-A1 | HETEROCYCLIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | THE UPJOHN COMPANY (US) | 1990-12-13 | — | — | WO | disclosed |