Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.43 |
| ▸ | PDE4A | P27815 | 6/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 6/20 | 0.43 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7735636 | 0.86 | SMN1; SMN2 (0.51) | SMN1; SMN2MEN1KMT2APDE4DPDE4A | |
| SCHEMBL7373976 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2MEN1KMT2APDE4DPDE4A | |
| SCHEMBL7374168 | 0.82 | MEN1 (0.60) | SMN1; SMN2MEN1KMT2APDE4DPDE4A | |
| SCHEMBL7725301 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1KMT2ANPC1PDE4D | |
| SCHEMBL7734322 | 0.76 | GAA (0.52) | SMN1; SMN2RAB9APDE4DPDE4APDE4B | |
| SCHEMBL7735278 | 0.74 | PDE4D (0.53) | SMN1; SMN2KMT2APDE4DPDE4APDE4B | |
| SCHEMBL7735233 | 0.73 | PDE5A (0.60) | SMN1; SMN2MEN1KMT2ARAB9APDE4D | |
| SCHEMBL7332617 | 0.71 | PDE4B (0.58) | PDE4DPDE4APDE4BPDE4CPOLB | |
| SCHEMBL7023339 | 0.71 | PDE4B (0.55) | PDE4DPDE4APDE4BPDE4CPOLB | |
| SCHEMBL2371289 | 0.70 | PDE4B (0.60) | PDE4DPDE4APDE4BPDE4CGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0796093-A4 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | EURO CELTIQUE SA (LU) | 1998-05-13 | — | — | EP | claimed |
| EP-0796093-A1 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | Euroceltique S.A. (LU) | 1997-09-24 | — | — | EP | claimed |
| US-5591776-A | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV | EURO-CELTIQUE, S.A. (LU) | 1997-01-07 | — | — | US | claimed |
| WO-1996021435-A1 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | EURO-CELTIQUE, S.A. (LU) | 1996-07-18 | — | — | WO | claimed |
| US-6153630-A | Phenylpyridyl compounds for inhibiting phosphodiesterase IV and methods of using same | EURO-CELTIQUE, S.A. (LU) | 2000-11-28 | — | — | US | disclosed |
| US-5889014-A | ASTHMA, ARTHRITIS, ALLERGIES, INFLAMMATION, DEPRESSION THERAPY | EURO-CELTIQUE, S.A. (LU) | 1999-03-30 | — | — | US | disclosed |
| EP-0796093-A4 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | EURO CELTIQUE SA (LU) | 1998-05-13 | — | — | EP | disclosed |
| EP-0796093-A1 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | Euroceltique S.A. (LU) | 1997-09-24 | — | — | EP | disclosed |
| US-5591776-A | Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV | EURO-CELTIQUE, S.A. (LU) | 1997-01-07 | — | — | US | disclosed |
| WO-1996021435-A1 | COMPOUNDS FOR AND METHOD OF INHIBITING PHOSPHODIESTERASE IV | EURO-CELTIQUE, S.A. (LU) | 1996-07-18 | — | — | WO | disclosed |