Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.47 |
| ▸ | PDE4A | P27815 | 8/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7725301 | 0.88 | SMN1; SMN2 (0.47) | SMN1; SMN2PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7734322 | 0.86 | GAA (0.52) | SMN1; SMN2PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7374168 | 0.86 | MEN1 (0.60) | SMN1; SMN2PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7376249 | 0.86 | SMN1; SMN2 (0.46) | SMN1; SMN2PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7373976 | 0.80 | SMN1; SMN2 (0.50) | SMN1; SMN2PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7735278 | 0.78 | PDE4D (0.53) | SMN1; SMN2PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7735233 | 0.77 | PDE5A (0.60) | SMN1; SMN2PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7332617 | 0.75 | PDE4B (0.58) | PDE4DPDE4APDE4BPDE4CPOLB | |
| SCHEMBL7023339 | 0.75 | PDE4B (0.55) | PDE4DPDE4APDE4BPDE4CPOLB | |
| SCHEMBL2371289 | 0.74 | PDE4B (0.60) | PDE4DPDE4APDE4BPDE4CGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6372770-B1 | TREATING A MAMMAL SUFFERING FROM A DISEASE STATE SELECTED FROM THE GROUP CONSISTING OF ASTHMA, ALLERGIES, INFLAMMATION, DEPRESSION, DEMENTIA, ATOPIC DISEASES, RHINITIS AND DISEASE STATES ASSOCIATED WITH ABNORMALLY HIGH PHYSIOLOGICAL LEVELS OF | EURO-CELTIQUE, S.A. | 2002-04-16 | — | — | US | disclosed |
| EP-0785927-A4 | NOVEL BENZOXAZOLES | EURO CELTIQUE SA (LU) | 1997-12-29 | — | — | EP | disclosed |
| US-5665737-A | PHOSPHODIESTERASE INHIBITORS | EURO-CELTIQUE, S.A. (LU) | 1997-09-09 | — | — | US | disclosed |
| EP-0785927-A1 | NOVEL BENZOXAZOLES | Euroceltique S.A. (LU) | 1997-07-30 | — | — | EP | disclosed |
| WO-1996011917-A1 | NOVEL BENZOXAZOLES | EURO-CELTIQUE, S.A. (LU) | 1996-04-25 | — | — | WO | disclosed |