Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CETP | P11597 | 4/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.42 |
| ▸ | ADAM9 | Q13443 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11513875 | 0.91 | HDAC3 (0.45) | CETPTSHRKEAP1LMNAMAPT | |
| SCHEMBL7379497 | 0.90 | CETP (0.47) | CETPTSHRMAPTSMN1; SMN2 | |
| SCHEMBL7381330 | 0.86 | TSHR (0.51) | CETPTSHRKEAP1SMN1; SMN2 | |
| SCHEMBL28373033 | 0.83 | CETP (0.45) | CETPTSHRMMP9MMP1MMP3 | |
| SCHEMBL10936389 | 0.79 | ALDH1A1 (0.46) | CETPTSHRMMP9MMP1MMP3 | |
| SCHEMBL11512016 | 0.77 | CETP (0.49) | CETPTSHRKEAP1LMNAMAPT | |
| SCHEMBL10890173 | 0.77 | MAPT (0.51) | CETPTSHRKEAP1LMNAMAPT | |
| SCHEMBL10784401 | 0.77 | CYP1A2 (0.51) | — | |
| SCHEMBL10936405 | 0.76 | SMN1; SMN2 (0.48) | TSHRMMP9MMP1MMP3ADAM17 | |
| SCHEMBL7342161 | 0.76 | ALDH1A1 (0.39) | CETP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0053902-B1 | PHOSPHINYLALKANOYL SUBSTITUTED PROLINES | E.R. Squibb & Sons, Inc. (US) | 1985-04-03 | — | — | EP | disclosed |
| US-4384123-A | Phosphinylalkanoyl substituted prolines | E. R. SQUIBB & SONS, INC. (US) | 1983-05-17 | — | — | US | disclosed |
| US-4337201-A | Phosphinylalkanoyl substituted prolines | E. R. SQUIBB & SONS, INC. (US) | 1982-06-29 | — | — | US | disclosed |
| EP-0053902-A1 | Phosphinylalkanoyl substituted prolines | E.R. Squibb & Sons, Inc. (US) | 1982-06-16 | — | — | EP | disclosed |
| US-4168267-A | Phosphinylalkanoyl prolines | E. R. SQUIBB & SONS, INC. (US) | 1979-09-18 | — | — | US | disclosed |