Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 17/20 | 0.58 |
| ▸ | PDE4B | Q07343 | 17/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 17/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 16/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7376342 | 0.88 | PDE4A (0.54) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL7376901 | 0.85 | PDE4A (0.65) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL7374697 | 0.74 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL6634116 | 0.71 | PDE4A (0.78) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL7395757 | 0.69 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL14455896 | 0.68 | PDE4A (0.84) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL84865 | 0.67 | PDE4A (1.00) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL7369940 | 0.66 | PDE4A (0.80) | PDE4APDE4BPDE4DPDE4C | |
| SCHEMBL6638544 | 0.66 | PDE4A (0.54) | PDE4APDE4BPDE4DPDE4CADORA3 | |
| SCHEMBL7400689 | 0.65 | PDE4A (0.81) | PDE4APDE4BPDE4DPDE4CADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0787132-A1 | BICYCLIC TETRAHYDRO PYRAZOLOPYRIDINES AND THEIR USE AS MEDICAMENTS | PFIZER INC. (US) | 1997-08-06 | — | — | EP | disclosed |
| WO-1996012720-A1 | BICYCLIC TETRAHYDRO PYRAZOLOPYRIDINES AND THEIR USE AS MEDICAMENTS | PFIZER INC. (US) | 1996-05-02 | — | — | WO | disclosed |