Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 15/20 | 0.56 |
| ▸ | ITGAV | P06756 | 14/20 | 0.56 |
| ▸ | ITGA2B | P08514 | 9/20 | 0.56 |
| ▸ | ITGB1 | P05556 | 7/20 | 0.56 |
| ▸ | ITGB5 | P18084 | 7/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7379400 | 0.93 | ITGB3 (0.58) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7379407 | 0.93 | ITGB3 (0.58) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7379428 | 0.92 | ITGB3 (0.47) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7378435 | 0.91 | ITGB3 (0.56) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7376050 | 0.90 | ITGB3 (0.61) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7376058 | 0.90 | ITGB3 (0.61) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL241018 | 0.89 | ITGB3 (0.59) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL241017 | 0.89 | ITGB3 (0.59) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7378767 | 0.88 | ITGB3 (0.46) | ITGB3ITGAVITGA2BITGB1ITGB5 | |
| SCHEMBL7377253 | 0.88 | ITGB3 (0.72) | ITGB3ITGAVITGA2BITGB1ITGB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | claimed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | disclosed |