Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 18/20 | 0.60 |
| ▸ | CTSL | P07711 | 11/20 | 0.60 |
| ▸ | CTSB | P07858 | 4/20 | 0.55 |
| ▸ | CTSS | P25774 | 7/20 | 0.47 |
| ▸ | GZMB | P10144 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6578014 | 0.83 | CTSK (0.81) | CTSKCTSLCTSBCTSS | |
| SCHEMBL6580107 | 0.82 | CTSK (0.69) | CTSKCTSLCTSBCTSSCASP1 | |
| SCHEMBL6580466 | 0.78 | CTSK (0.55) | CTSKCTSLCTSBCTSSCASP1 | |
| SCHEMBL6577712 | 0.77 | CTSK (0.90) | CTSKCTSLCTSBCTSS | |
| SCHEMBL6580314 | 0.76 | CTSK (0.69) | CTSKCTSLCTSBCTSS | |
| SCHEMBL6582040 | 0.76 | CTSK (0.69) | CTSKCTSLCTSBCTSS | |
| SCHEMBL6580343 | 0.76 | CTSK (0.83) | CTSKCTSLCTSBCTSS | |
| SCHEMBL6578154 | 0.75 | CTSK (0.70) | CTSKCTSLCTSBCTSS | |
| SCHEMBL7585969 | 0.75 | CTSK (1.00) | CTSKCTSLCTSBCTSS | |
| SCHEMBL6578258 | 0.74 | CTSK (0.74) | CTSKCTSLCTSBCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0936912-A4 | INHIBITORS OF CYSTEINE PROTEASE | SMITHKLINE BEECHAM CORP (US) | 1999-10-13 | — | — | EP | claimed |
| EP-0936912-A1 | INHIBITORS OF CYSTEINE PROTEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1999-08-25 | — | — | EP | claimed |
| WO-1998005336-A1 | INHIBITORS OF CYSTEINE PROTEASE | SMITHKLINE BEECHAM CORPORATION (US) | 1998-02-12 | — | — | WO | claimed |