SCHEMBL7377757

SCHEMBL7377757

COc1ccccc1N(C)C(=O)c1ccc(NC(=O)c2ccccc2-c2ccc(C)cc2)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.52
ALDH1A1 P00352 3/20 0.52
RAB9A P51151 3/20 0.52
POLB P06746 2/20 0.52
GAA P10253 2/20 0.52
HTT P42858 1/20 0.49
KMT2A Q03164 5/20 0.48
MEN1 O00255 3/20 0.48
AHR P35869 1/20 0.48
KDM4E B2RXH2 2/20 0.47
LMNA P02545 1/20 0.47
TP53 P04637 2/20 0.45
SMN1; SMN2 Q16637 3/20 0.45
RECQL P46063 1/20 0.45
NPC1 O15118 1/20 0.45
MAPK1 P28482 1/20 0.45
CHRNB2 P17787 1/20 0.45
CHRNB4 P30926 1/20 0.45
CHRNA3 P32297 1/20 0.45
CHRNA4 P43681 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7368652 0.89 RECQL (0.48) MAPTALDH1A1RAB9APOLBGAA
SCHEMBL7379111 0.88 POLB (0.52) MAPTALDH1A1RAB9APOLBGAA
SCHEMBL7374527 0.88 MAPT (0.47) MAPTALDH1A1RAB9APOLBGAA
SCHEMBL7372435 0.87 RECQL (0.46) MAPTALDH1A1RAB9APOLBGAA
SCHEMBL7376794 0.87 MEN1 (0.53) MAPTALDH1A1RAB9APOLBGAA
SCHEMBL7372735 0.87 CHRNB2 (0.49) MAPTALDH1A1RAB9APOLBGAA
SCHEMBL7376741 0.87 CHRNB2 (0.49) ALDH1A1RAB9APOLBGAAHTT
SCHEMBL7379522 0.87 NPC1 (0.56) MAPTALDH1A1RAB9APOLBGAA
SCHEMBL7374040 0.87 CHRNB2 (0.56) MAPTALDH1A1RAB9APOLBGAA
SCHEMBL7373554 0.86 RECQL (0.46) MAPTALDH1A1RAB9APOLBGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6211242-B1 CARDIOVASCULAR DISORDERS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 2001-04-03 US disclosed
EP-0757670-B1 BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS FUJISAWA PHARMACEUTICAL CO (JP) 1999-01-13 EP disclosed
WO-1995029152-A1 BENZAMIDE DERIVATIVES AS VASOPRESSIN ANTAGONISTS FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1995-11-02 WO disclosed