Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.46 |
| ▸ | MERTK | Q12866 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 7/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7369745 | 0.87 | NPC1 (0.49) | MITFRAB9AKAT2BMAPTCDK5 | |
| SCHEMBL7374301 | 0.84 | MAPT (0.53) | MITFRAB9AMAPTL3MBTL1CDK5 | |
| SCHEMBL7374361 | 0.84 | MAPT (0.59) | MITFRAB9AMAPTL3MBTL1CDK5 | |
| SCHEMBL7370622 | 0.83 | MAPT (0.56) | MITFRAB9AMAPTL3MBTL1CDK5 | |
| SCHEMBL7378902 | 0.81 | MAPT (0.55) | MITFRAB9AMAPTNPC1KDM4E | |
| SCHEMBL25831547 | 0.78 | MAPT (0.58) | RAB9AKAT2BMERTKMAPTL3MBTL1 | |
| SCHEMBL20919464 | 0.78 | MAPT (0.58) | MERTKMAPTL3MBTL1TDP1CYP3A4 | |
| SCHEMBL22481564 | 0.77 | MAPT (0.68) | RAB9AKAT2BMERTKMAPTL3MBTL1 | |
| SCHEMBL7373815 | 0.76 | CDK5 (0.53) | MITFRAB9AMAPTL3MBTL1CDK5 | |
| SCHEMBL7378291 | 0.76 | CDC7 (0.53) | MITFRAB9AMAPTCDK5CDK5R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1085871-A4 | QUINAZOLINONE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL MYERS SQUIBB CO (US) | 2001-10-04 | — | — | EP | disclosed |
| EP-1085871-A1 | QUINAZOLINONE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-03-28 | — | — | EP | disclosed |
| US-6087368-A | AN ENZYME INHIBITOR TREATING ERECTILE DYSFUNCTION OF SEX DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-07-11 | — | — | US | disclosed |
| WO-1999064004-A1 | QUINAZOLINONE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-12-16 | — | — | WO | disclosed |