Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | CRHBP | P24387 | 1/20 | 0.55 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | CD38 | P28907 | 1/20 | 0.50 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | ASPH | Q12797 | 1/20 | 0.47 |
| ▸ | RIOX2 | Q8IUF8 | 1/20 | 0.47 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7378996 | 0.87 | ALDH1A1 (0.57) | MAPTMEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL7374361 | 0.84 | MAPT (0.59) | MAPTMEN1KMT2AHPGDNPC1 | |
| SCHEMBL7374301 | 0.84 | MAPT (0.53) | MAPTMEN1KMT2ANPC1RAB9A | |
| SCHEMBL7370622 | 0.83 | MAPT (0.56) | MAPTMEN1KMT2AHPGDNPC1 | |
| SCHEMBL7377328 | 0.83 | PDE5A (0.48) | MAPTMEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL12100638 | 0.82 | MAPT (0.58) | MAPTMEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL4309629 | 0.82 | MAPT (0.62) | MAPTMEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL12099879 | 0.81 | KMT2A (0.51) | MAPTMEN1KMT2ACRHBPCRHR2 | |
| SCHEMBL7378010 | 0.81 | MITF (0.49) | MAPTCRHBPCRHR2HPGDNPC1 | |
| SCHEMBL7374362 | 0.80 | MAPT (0.56) | MAPTMEN1KMT2AHPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1085871-A4 | QUINAZOLINONE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL MYERS SQUIBB CO (US) | 2001-10-04 | — | — | EP | disclosed |
| EP-1085871-A1 | QUINAZOLINONE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 2001-03-28 | — | — | EP | disclosed |
| US-6087368-A | AN ENZYME INHIBITOR TREATING ERECTILE DYSFUNCTION OF SEX DISORDERS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2000-07-11 | — | — | US | disclosed |
| WO-1999064004-A1 | QUINAZOLINONE INHIBITORS OF cGMP PHOSPHODIESTERASE | BRISTOL-MYERS SQUIBB COMPANY (US) | 1999-12-16 | — | — | WO | disclosed |