Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.53 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 7/20 | 0.38 |
| ▸ | MAPK12 | P53778 | 7/20 | 0.38 |
| ▸ | MAPK11 | Q15759 | 7/20 | 0.38 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.38 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.37 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.37 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | GCGR | P47871 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7376921 | 0.91 | PDE10A (0.54) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL7377231 | 0.84 | PDE10A (0.60) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL7352490 | 0.84 | PDE10A (0.60) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL9698897 | 0.84 | PDE10A (0.48) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL9700069 | 0.82 | PDE10A (0.55) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL9203616 | 0.81 | PDE10A (0.48) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL9700092 | 0.81 | PDE10A (0.56) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL7378897 | 0.81 | PDE10A (0.48) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL9198368 | 0.80 | PDE10A (0.53) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 | |
| SCHEMBL9701112 | 0.79 | PDE10A (0.57) | PDE10ATGFBR1ATMSMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1990015534-A1 | MONOKINE ACTIVITY INTERFERENCE | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-27 | — | — | WO | claimed |
| EP-0411754-A2 | Medicament for the inhibition of interleukin-1 or tumor necrosis factor production by monocytes and/or macrophages | SMITHKLINE BEECHAM CORPORATION (US) | 1991-02-06 | — | — | EP | disclosed |
| WO-1990015534-A1 | MONOKINE ACTIVITY INTERFERENCE | SMITHKLINE BEECHAM CORPORATION (US) | 1990-12-27 | — | — | WO | disclosed |