Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.56 |
| ▸ | MAPK13 | O15264 | 9/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 9/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 9/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 9/20 | 0.49 |
| ▸ | GCGR | P47871 | 4/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 3/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7352490 | 0.96 | PDE10A (0.60) | PDE10AMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7377231 | 0.96 | PDE10A (0.60) | PDE10AMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL11473380 | 0.90 | PDE10A (0.51) | PDE10AMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9524935 | 0.85 | TGFBR1 (0.50) | PDE10ATGFBR1SMN1; SMN2KDM4EALOX15 | |
| SCHEMBL9700043 | 0.83 | TGFBR1 (0.60) | PDE10AMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7376921 | 0.83 | PDE10A (0.54) | PDE10AMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9436323 | 0.82 | TGFBR1 (0.63) | PDE10AMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9524502 | 0.81 | PDE10A (0.50) | PDE10AMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL7378261 | 0.81 | PDE10A (0.53) | PDE10AMAPK13MAPK12MAPK11MAPK14 | |
| SCHEMBL9198368 | 0.81 | PDE10A (0.53) | PDE10AMAPK13MAPK12MAPK11MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5145858-A | Antiinflammatory | SMITHKLINE BEECHAM CORP. (US) | 1992-09-08 | — | — | US | disclosed |
| WO-1990003789-A1 | PYRROLO[1,2-a]IMIDAZOLE AND IMIDAZO[1,2-a]PYRIDINE DERIVATIVES AND THEIR USE AS 5-LYPOXYGENASE PATHWAY INHIBITORS | SMITHKLINE BEECHAM CORPORATION (US) | 1990-04-19 | — | — | WO | disclosed |
| EP-0364204-A1 | Pyrrolo[1,2-a]imidazole and imidazo[1,2-a]pyridine derivatives and their use as 5-lipoxygenase pathway inhibitors | SMITHKLINE BEECHAM CORPORATION (US) | 1990-04-18 | — | — | EP | disclosed |