Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 8/20 | 0.62 |
| ▸ | ABCC1 | P33527 | 3/20 | 0.62 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.56 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.55 |
| ▸ | TSHR | P16473 | 3/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12835497 | 0.86 | ABCG2 (0.60) | ABCG2ABCC1CYP1A1CYP1B1CYP1A2 | |
| SCHEMBL7374619 | 0.80 | ABCG2 (0.69) | ABCG2ABCC1CYP1A1CYP1B1CYP1A2 | |
| SCHEMBL4282126 | 0.80 | ABCG2 (0.69) | ABCG2ABCC1CYP1A1CYP1B1CYP1A2 | |
| SCHEMBL8875406 | 0.77 | ABCG2 (0.64) | ABCG2ABCC1CYP1A1CYP1B1CYP1A2 | |
| SCHEMBL18243048 | 0.76 | KDM4E (0.64) | KDM4EALDH1A1MAPTCYP3A4HSD17B10 | |
| SCHEMBL29993383 | 0.75 | ABCG2 (1.00) | ABCG2ABCC1CYP1A1CYP1B1KDM4E | |
| SCHEMBL253523 | 0.75 | ABCG2 (1.00) | ABCG2ABCC1CYP1A1CYP1B1KDM4E | |
| SCHEMBL8876891 | 0.75 | ABCG2 (0.62) | ABCG2ABCC1CYP1A1CYP1B1CYP1A2 | |
| SCHEMBL8876901 | 0.75 | ABCG2 (0.62) | ABCG2ABCC1CYP1A1CYP1B1CYP1A2 | |
| SCHEMBL31234378 | 0.75 | KDM4E (0.52) | ABCG2ABCC1CYP1A1CYP1B1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1115718-A1 | HYDROXYFLAVONE DERIVATIVES AS TAU PROTEIN KINASE 1 INHIBITORS | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-07-18 | — | — | EP | disclosed |
| WO-2000017184-A1 | HYDROXYFLAVONE DERIVATIVES AS TAU PROTEIN KINASE 1 INHIBITORS | MITSUBISHI CHEMICAL CORPORATION (JP) | 2000-03-30 | — | — | WO | disclosed |