SCHEMBL253523

SCHEMBL253523

COc1c(-c2ccccc2)oc2ccccc2c1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCG2 Q9UNQ0 5/20 1.00
KDM4E B2RXH2 9/20 0.74
ALDH1A1 P00352 7/20 0.74
CYP3A4 P08684 6/20 0.74
HSD17B10 Q99714 6/20 0.74
MAPT P10636 5/20 0.74
KMT2A Q03164 4/20 0.74
HPGD P15428 3/20 0.74
CYP2C9 P11712 3/20 0.74
TSHR P16473 3/20 0.74
CYP2C19 P33261 3/20 0.74
MEN1 O00255 3/20 0.74
CYP2D6 P10635 2/20 0.74
THRB P10828 1/20 0.74
TDP1 Q9NUW8 1/20 0.74
ABCC1 P33527 1/20 0.65
GAA P10253 2/20 0.62
LMNA P02545 2/20 0.62
HTT P42858 1/20 0.62
NPSR1 Q6W5P4 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29993383 1.00 ABCG2 (1.00) ABCG2KDM4EALDH1A1CYP3A4HSD17B10
SCHEMBL4650702 0.89 ABCG2 (1.00) ABCG2KDM4EALDH1A1CYP3A4HSD17B10
SCHEMBL5796864 0.88 ABCG2 (0.78) ABCG2KDM4EALDH1A1CYP3A4HSD17B10
SCHEMBL4649960 0.85 KDM4E (0.76) ABCG2KDM4EALDH1A1CYP3A4HSD17B10
3,6-Dimethoxyflavone SCHEMBL4649913 0.85 KDM4E (1.00) ABCG2KDM4EALDH1A1CYP3A4HSD17B10
3,7-Dimethoxyflavone SCHEMBL4278796 0.85 ALDH1A1 (1.00) ABCG2KDM4EALDH1A1CYP3A4HSD17B10
SCHEMBL17786415 0.84 HSD17B10 (0.74) ABCG2KDM4EALDH1A1CYP3A4HSD17B10
SCHEMBL7162949 0.84 KDM4E (0.74) ABCG2KDM4EALDH1A1CYP3A4HSD17B10
SCHEMBL2319299 0.83 ABCG2 (0.70) ABCG2KDM4EALDH1A1CYP3A4HSD17B10
SCHEMBL10769734 0.83 ABCG2 (0.72) ABCG2KDM4EALDH1A1CYP3A4HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1421 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250282871-A1 PHARMACEUTICAL COMBINATION AND USE THEREOF TIANJIN LIPOGEN TECH CO LTD (CN) 2025-09-11 US claimed
US-12239655-B2 Combined modalities for nucleosides and/or NADPH oxidase (NOX) inhibitors as myeloid-specific antiviral agents EMORY UNIVERSITY (US) 2025-03-04 US claimed
EP-4384027-A1 COMPOSITION COMPRISING A NUTRIENT AND A TASTE MODULATOR Firmenich SA (CH) 2024-06-19 EP claimed
WO-2024114248-A1 CITRUS FRUIT EXTRACT, AND PREPARATION METHOD THEREFOR AND USE THEREOF 三峡大学 2024-06-06 WO claimed
EP-4342492-A1 PHARMACEUTICAL COMBINATION AND USE THEREOF Tianjin Lipogen Technology Co., Ltd (CN) 2024-03-27 EP claimed
EP-4329499-A1 FLAVOR-MODIFYING COMPOSITIONS CONTAINING LACTASE Firmenich SA (CH) 2024-03-06 EP claimed
CN-116268070-A Polyphenol additive capable of improving frozen storage quality of non-rinsed minced fillet and application thereof 中南林业科技大学 2023-06-23 CN claimed
WO-2023108169-A2 METHODS AND COMPOSITIONS FOR THE BIOSYNTHESIS AND USE OF DEMETHYLATED POLYMETHOXY FLAVONES RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY (US) 2023-06-15 WO claimed
WO-2023072604-A1 COMPOSITION COMPRISING A NUTRIENT AND A TASTE MODULATOR FIRMENICH SA (CH) 2023-05-04 WO claimed
CN-115948362-A Oxygen methyltransferase participating in biosynthesis of polymethoxyflavone in citrus peel, coding gene, amplification primer pair and application 浙江大学 2023-04-11 CN claimed
US-20020016358-A1 Cosmetic composition NOF CORPORATION 2002-02-07 US claimed
US-20020006953-A1 MODIFICATION OF CHOLESTEROL CONCENTRATIONS WITH CITUS PHYTOCHEMICALS TROPICANA PRODUCTS, INC. 2002-01-17 US claimed
EP-1147764-A2 Cosmetic composition NOF CORPORATION (JP) 2001-10-24 EP claimed
CN-1318366-A Cosmetics composition NIPPON OILS & FATS CO LTD (JP) 2001-10-24 CN claimed
WO-2001070029-A1 COMPOSITIONS AND METHODS OF TREATING, REDUCING, AND PREVENTING CARDIOVASCULAR DISEASES AND DISORDERS WITH POLYMETHOXYFLAVONES KGK SYNERGIE (CA) 2001-09-27 WO claimed
WO-2001032160-A2 MODIFICATION OF CHOLESTEROL CONCENTRATIONS WITH CITRUS PHYTOCHEMICALS TROPICANA PRODUCTS, INC. (US) 2001-05-10 WO claimed
WO-2001021137-A1 EXTRACTS OF ORANGE PEEL FOR PREVENTION AND TREATMENT OF CANCER RUTGERS, THE STATE UNIVERSITY (US) 2001-03-29 WO claimed
WO-2001003681-A2 USE OF FLAVONES, COUMARINS AND RELATED COMPOUNDS TO TREAT INFECTIONS PRENDERGAST PATRICK T (IE) 2001-01-18 WO claimed
EP-0915864-A1 GASTROPROTECTIVE FLAVONE/FLAVANONE COMPOUNDS WITH THERAPEUTIC EFFECT ON INFLAMMATORY BOWEL DISEASE Dong A Pharmaceutical Co. Ltd. (KR) 1999-05-19 EP claimed
WO-1998004541-A1 GASTROPROTECTIVE FLAVONE/FLAVANONE COMPOUNDS WITH THERAPEUTIC EFFECT ON INFLAMMATORY BOWEL DISEASE DONG A PHARMACEUTICAL CO., LTD. (KR) 1998-02-05 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020016358-A1 Cosmetic composition PLIN5, TEAD3, CUTA ABCG2 3238/4885KDM4E 365/4885ALDH1A1 3843/4885
US-12239655-B2 Combined modalities for nucleosides and/or NADPH oxidase (NOX) inhibitors as myeloid-specific antiviral agents NOX1, NOX3, NOX4 ABCG2 3807/4885KDM4E 1610/4885ALDH1A1 1165/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.