Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 7/20 | 0.53 |
| ▸ | ITGA2B | P08514 | 7/20 | 0.53 |
| ▸ | ITGAV | P06756 | 6/20 | 0.53 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.47 |
| ▸ | ITGB5 | P18084 | 3/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.43 |
| ▸ | KCNK3 | O14649 | 2/20 | 0.43 |
| ▸ | KCNK9 | Q9NPC2 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | FKBP5 | Q13451 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7380126 | 0.90 | ITGB3 (0.53) | SMN1; SMN2ITGB3ITGA2BITGAVITGB1 | |
| SCHEMBL7376564 | 0.88 | ITGB3 (0.67) | SMN1; SMN2ITGB3ITGA2BITGAVITGB1 | |
| SCHEMBL7379952 | 0.87 | ITGB3 (0.48) | SMN1; SMN2ITGB3ITGA2BITGAVITGB1 | |
| SCHEMBL7378623 | 0.86 | SMN1; SMN2 (0.58) | SMN1; SMN2ITGB3ITGA2BITGAVITGB1 | |
| SCHEMBL7508102 | 0.85 | ITGB3 (0.48) | SMN1; SMN2ITGB3ITGA2BITGAVITGB1 | |
| SCHEMBL7861974 | 0.84 | ITGB3 (0.64) | SMN1; SMN2ITGB3ITGA2BITGAVITGB1 | |
| SCHEMBL7373424 | 0.84 | ITGB3 (0.64) | SMN1; SMN2ITGB3ITGA2BITGAVITGB1 | |
| SCHEMBL7378811 | 0.82 | PTGER4 (0.48) | SMN1; SMN2ITGB3ITGA2BITGAVITGB1 | |
| SCHEMBL7380550 | 0.80 | ITGB3 (0.43) | SMN1; SMN2ITGB3ITGA2BITGAVITGB1 | |
| SCHEMBL7380190 | 0.79 | KCNK3 (0.46) | SMN1; SMN2ITGB3ITGA2BITGAVITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0891325-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1999-01-20 | — | — | EP | disclosed |
| WO-1997036859-A1 | PARA-SUBSTITUTED PHENYLPROPANOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | disclosed |