SCHEMBL7378640

SCHEMBL7378640

O=C(O)/C=C/c1cc(Cl)ccc1Cl

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PTGER3 P43115 3/20 0.55
PTGER2 P43116 3/20 0.55
MAPT P10636 3/20 0.55
ITGB2 P05107 2/20 0.55
ICAM1 P05362 2/20 0.55
ITGAL P20701 2/20 0.55
TBXA2R P21731 2/20 0.55
PTGFR P43088 2/20 0.55
PTGIR P43119 2/20 0.55
PTGDR Q13258 2/20 0.55
PLA2G1B P04054 1/20 0.55
ATG4B Q9Y4P1 1/20 0.55
PTGER1 P34995 2/20 0.51
LMNA P02545 1/20 0.48
PTGER4 P35408 1/20 0.48
ALDH1A1 P00352 3/20 0.47
KDM4E B2RXH2 1/20 0.47
GAA P10253 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
TP53 P04637 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29406682 1.00 PTGER3 (0.55) PTGER3PTGER2MAPTITGB2ICAM1
SCHEMBL7378645 1.00 PTGER3 (0.55) PTGER3PTGER2MAPTITGB2ICAM1
SCHEMBL481451 0.85 MAPT (0.65) PTGER3PTGER2MAPTITGB2ICAM1
SCHEMBL165227 0.85 MAPT (0.65) PTGER3PTGER2MAPTITGB2ICAM1
SCHEMBL29419102 0.85 MAPT (0.65) PTGER3PTGER2MAPTITGB2ICAM1
SCHEMBL1674366 0.83 MIF (0.54) PTGER3PTGER2MAPTITGB2ICAM1
SCHEMBL7687333 0.83 MAPT (0.46) PTGER3PTGER2MAPTITGB2ICAM1
SCHEMBL7687335 0.83 MAPT (0.46) PTGER3PTGER2MAPTITGB2ICAM1
Hydrochloric Acid SCHEMBL6822024 0.83 MAPT (0.63) PTGER3PTGER2MAPTITGB2ICAM1
SCHEMBL11459860 0.83 MAPT (0.63) PTGER3PTGER2MAPTITGB2ICAM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118930859-A Cinnamic acid modified polyarylene sulfide and preparation method thereof 新凝合科技(成都)有限公司 2024-11-12 CN claimed
CN-118930859-A Cinnamic acid modified polyarylene sulfide and preparation method thereof 新凝合科技(成都)有限公司 2024-11-12 CN disclosed
CN-116768792-B Cinnamamide-hydroxypyridone derivative, and preparation method and application thereof 浙江工业大学 2024-10-18 CN disclosed
CN-117355521-A Heteroaryl inhibitors of plasma kallikrein 武田药品工业株式会社 2024-01-05 CN disclosed
CN-117343072-A 1-substituted cinnamoyl-2-oxo lycorine compound and preparation method and application thereof 山东达因海洋生物制药股份有限公司 2024-01-05 CN disclosed
CN-116768792-A Cinnamamide-hydroxypyridone derivative, and preparation method and application thereof 浙江工业大学 2023-09-19 CN disclosed
WO-2023000398-A1 LYCORINE β-ARYL ACRYLATE DERIVATIVE, AND PREPARATION METHOD THEREFOR AND USE THEREOF 山东达因海洋生物制药股份有限公司 2023-01-26 WO disclosed
CN-110156703-B Phenazine derivatives as TrxR1 inhibitors, intermediates, and methods of making and using the same 中国药科大学 2022-08-05 CN disclosed
CN-113416199-B Lycorine beta-aryl acrylate derivative and preparation method and application thereof 山东达因海洋生物制药股份有限公司 2022-03-01 CN disclosed
CN-113416199-A Lycorine beta-aryl acrylate derivative and preparation method and application thereof 山东达因海洋生物制药股份有限公司 2021-09-21 CN disclosed
CN-112876365-A Methyl rupestonic acid derivative containing cinnamoyl and preparation method and application thereof 中国科学院新疆理化技术研究所 2021-06-01 CN disclosed
CN-110156703-A As the phenazene derivative of TrxR1 inhibitor, intermediate product and its preparation method and application 中国药科大学 2019-08-23 CN disclosed
US-9204652-B2 Antibacterial agent, substrate surface treatment method using the same, antibacterial agent composition, and substrate surface treatment method using the same CENTRAL GLASS COMPANY, LIMITED (JP) 2015-12-08 US disclosed
EP-2622960-A1 ANTIBACTERIAL AGENT, SUBSTRATE SURFACE TREATMENT METHOD USING THE SAME, ANTIBACTERIAL AGENT COMPOSITION, AND SUBSTRATE SURFACE TREATMENT METHOD USING THE SAME Central Glass Company, Limited (JP) 2013-08-07 EP disclosed
US-20130189220-A1 Antibacterial Agent, Substrate Surface Treatment Method Using The Same, Antibacterial Agent Composition, And Substrate Surface Treatment Method Using The Same CENTRAL GLASS COMPANY, LIMITED (JP) 2013-07-25 US disclosed
WO-1997023202-A1 SUBTYPE-SELECTIVE NMDA RECEPTOR LIGANDS AND THE USE THEREOF STATE OF OREGON, acting by and through THE OREGON STATE BOARD OF HIGHER EDUCATION, acting for and on behalf of THE OREGON HEALTH SCIENCES UNIVERSITYA ND THE UNIVERSITY OF OREGON, EUGENE OREGON (US) 1997-07-03 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130189220-A1 Antibacterial Agent, Substrate Surface Treatment Method Using The Same, Antibacterial Agent Composition, And Substrate Surface Treatment Method Using The Same SEM1, CD81, VMA21 PTGER3 4820/4885PTGER2 4628/4885MAPT 3386/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.