SCHEMBL7378733

SCHEMBL7378733

NC(=O)C1CCN(CCNc2ccncc2)C1=O

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 2/20 0.35
CYP2C9 P11712 1/20 0.35
GRIN2B Q13224 1/20 0.35
KEAP1 Q14145 1/20 0.34
NFE2L2 Q16236 1/20 0.34
SCN9A Q15858 1/20 0.34
TPSAB1 Q15661 1/20 0.34
TPSD1 Q9BZJ3 1/20 0.34
TPSG1 Q9NRR2 1/20 0.34
KMT2A Q03164 2/20 0.33
MEN1 O00255 1/20 0.33
EPHX1 P07099 1/20 0.32
CDK2 P24941 2/20 0.32
CCNA2 P20248 1/20 0.32
CCNA1 P78396 1/20 0.32
ROCK2 O75116 3/20 0.32
ROCK1 Q13464 3/20 0.32
PKN2 Q16513 3/20 0.32
RPS6KA5 O75582 2/20 0.32
LRRK2 Q5S007 2/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7540081 1.00 CYP2D6 (0.35) CYP2D6CYP2C9GRIN2BKEAP1NFE2L2
Trifluoroacetic Acid SCHEMBL7376993 0.93 GPR6 (0.36) CYP2D6CYP2C9GRIN2BKMT2AL3MBTL1
Trifluoroacetic Acid SCHEMBL7370016 0.93 GPR6 (0.36) CYP2D6CYP2C9GRIN2BKMT2AL3MBTL1
Trifluoroacetic Acid SCHEMBL7921642 0.93 GPR6 (0.36) CYP2D6CYP2C9GRIN2BKMT2AL3MBTL1
SCHEMBL7413226 0.82 MAPT (0.33) CYP2D6CYP2C9GRIN2BKEAP1NFE2L2
SCHEMBL7375396 0.82 MAPT (0.33) CYP2D6CYP2C9GRIN2BKEAP1NFE2L2
Trifluoroacetic Acid SCHEMBL7921647 0.79 DPP4 (0.38) CYP2D6CYP2C9GRIN2BKMT2AL3MBTL1
Trifluoroacetic Acid SCHEMBL7370017 0.79 DPP4 (0.38) CYP2D6CYP2C9GRIN2BKMT2AL3MBTL1
SCHEMBL2686767 0.78 MEN1 (0.41) CYP2C9KMT2AMEN1CYP3A4ALDH1A1
Trifluoroacetic Acid SCHEMBL7377780 0.75 GPR6 (0.38) CYP2C9ALDH1A1L3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1086099-A4 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARM PROD INC (US) 2002-01-02 EP claimed
US-6281227-B1 INHIBITORS OF THE ACTIVITY OF FACTOR XA. AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2001-08-28 US claimed
EP-1086099-A1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS Aventis Pharmaceuticals Products Inc. (US) 2001-03-28 EP claimed
WO-1999062904-A1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) 1999-12-09 WO claimed
EP-1086099-A4 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARM PROD INC (US) 2002-01-02 EP disclosed
US-6281227-B1 INHIBITORS OF THE ACTIVITY OF FACTOR XA. AVENTIS PHARMA DEUTSCHLAND GMBH (DE) 2001-08-28 US disclosed
EP-1086099-A1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS Aventis Pharmaceuticals Products Inc. (US) 2001-03-28 EP disclosed
WO-1999062904-A1 SULFONIC ACID OR SULFONYLAMINO N-(HETEROARALKYL)-AZAHETEROCYCLYLAMIDE COMPOUNDS AVENTIS PHARMACEUTICALS PRODUCTS INC. (US) 1999-12-09 WO disclosed