SCHEMBL7378965

SCHEMBL7378965

O=C(NO)[C@@H](Cc1c[nH]c2ccccc12)NS(=O)(=O)c1ccccc1

nearest known ligand 0.89

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
MMP9 P14780 14/20 0.89
MMP2 P08253 12/20 0.89
HDAC8 Q9BY41 2/20 0.69
HDAC6 Q9UBN7 2/20 0.69
HDAC2 Q92769 1/20 0.69
KCNA5 P22460 2/20 0.61
NR3C1 P04150 1/20 0.60
MEN1 O00255 1/20 0.59
POLB P06746 1/20 0.59
KMT2A Q03164 1/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7378962 1.00 MMP9 (0.89) MMP9MMP2HDAC8HDAC6HDAC2
SCHEMBL7379195 0.92 MMP9 (0.84) MMP9MMP2HDAC8HDAC6HDAC2
SCHEMBL7379197 0.92 MMP9 (0.84) MMP9MMP2HDAC8HDAC6HDAC2
SCHEMBL7382067 0.91 MMP9 (0.82) MMP9MMP2HDAC8HDAC6HDAC2
SCHEMBL7382065 0.91 MMP9 (0.82) MMP9MMP2HDAC8HDAC6HDAC2
SCHEMBL3875616 0.91 MMP9 (0.83) MMP9MMP2HDAC8HDAC6HDAC2
SCHEMBL6720186 0.89 MMP9 (0.89) MMP9MMP2KCNA5MEN1POLB
SCHEMBL5191094 0.89 MMP9 (0.89) MMP9MMP2KCNA5MEN1POLB
SCHEMBL7374860 0.88 MMP9 (0.78) MMP9MMP2KCNA5
SCHEMBL7379813 0.88 MMP9 (0.78) MMP9MMP2KCNA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0934267-B1 ALPHA-AMINO SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS UPJOHN CO (US) 2002-01-30 EP claimed
EP-0934267-A1 $g(a)-AMINO SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1999-08-11 EP claimed
US-5804593-A FOR TREATMENT OF CONNECTIVE TISSUE DEGRADATION, OSTEO-, RHEUMATOID-, AND SEPTIC ARTHRITIS; OSTEOPENIAS, OSTEOPOROSIS, CORNEAL ULCERATION, PERIDONTAL DISEASE, GASTRIC ULCERS. PHARMACIA & UPJOHN COMPANY (US) 1998-09-08 US claimed
WO-1998017645-A1 α-AMINO SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1998-04-30 WO claimed
EP-0934267-B1 ALPHA-AMINO SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS UPJOHN CO (US) 2002-01-30 EP disclosed
EP-0934267-A1 $g(a)-AMINO SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1999-08-11 EP disclosed
US-5804593-A FOR TREATMENT OF CONNECTIVE TISSUE DEGRADATION, OSTEO-, RHEUMATOID-, AND SEPTIC ARTHRITIS; OSTEOPENIAS, OSTEOPOROSIS, CORNEAL ULCERATION, PERIDONTAL DISEASE, GASTRIC ULCERS. PHARMACIA & UPJOHN COMPANY (US) 1998-09-08 US disclosed
WO-1998017645-A1 α-AMINO SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS PHARMACIA & UPJOHN COMPANY (US) 1998-04-30 WO disclosed