Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 2/20 | 0.38 |
| ▸ | SORT1 | Q99523 | 2/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | MME | P08473 | 2/20 | 0.36 |
| ▸ | ACE2 | Q9BYF1 | 4/20 | 0.35 |
| ▸ | ACE | P12821 | 3/20 | 0.35 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.35 |
| ▸ | LTA4H | P09960 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7383996 | 0.93 | MMP1 (0.38) | GRNSORT1DGAT1GAAMAPK1 | |
| SCHEMBL7379326 | 0.82 | GAA (0.42) | GRNSORT1GAAMMEACE2 | |
| SCHEMBL7379064 | 0.80 | GRN (0.42) | GRNSORT1GAAACE2ACE | |
| SCHEMBL5869916 | 0.79 | ACE2 (0.38) | GRNSORT1DGAT1GAAMAPK1 | |
| SCHEMBL3711706 | 0.79 | ACE2 (0.41) | GRNSORT1MMEACE2ACE | |
| SCHEMBL7384899 | 0.79 | GRN (0.37) | GRNSORT1GAAMMEACE2 | |
| SCHEMBL3715236 | 0.77 | ACE2 (0.39) | GRNSORT1GAAACE2ACE | |
| SCHEMBL7375023 | 0.77 | ACE2 (0.39) | GRNSORT1GAAMAPK1MME | |
| SCHEMBL5869579 | 0.76 | ACE2 (0.54) | GRNSORT1DGAT1GAAMAPK1 | |
| SCHEMBL3712784 | 0.76 | ACE2 (0.39) | GRNSORT1MMEACE2ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | claimed |
| WO-2002039997-A2 | ACE-2 MODULATING COMPOUNDS AND USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2002-05-23 | — | — | WO | disclosed |
| EP-1183019-A2 | ACE-2 INHIBITING COMPOUNDS AND METHODS OF USE THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000066104-A2 | ACE-2 INHIBITING COMPOUNDS AND METHODS OF USE THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2000-11-09 | — | — | WO | disclosed |