Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1C | Q13936 | 15/20 | 0.61 |
| ▸ | CACNA1F | O60840 | 12/20 | 0.54 |
| ▸ | CACNA1D | Q01668 | 12/20 | 0.54 |
| ▸ | CACNA1S | Q13698 | 12/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.51 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7380848 | 0.89 | CACNA1C (0.58) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL7380847 | 0.89 | CACNA1C (0.58) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL11829575 | 0.87 | ADORA3 (0.69) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL7377444 | 0.84 | CACNA1C (0.61) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL11834840 | 0.84 | CACNA1C (0.65) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL11690943 | 0.83 | ADORA3 (0.61) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL11669883 | 0.83 | CACNA1C (0.59) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL7377945 | 0.82 | CACNA1C (0.59) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL11754968 | 0.82 | CACNA1C (0.58) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 | |
| SCHEMBL7275991 | 0.82 | CACNA1F (0.82) | CACNA1CCACNA1FCACNA1DCACNA1SADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4370334-A | VASODILATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-01-25 | — | — | US | claimed |
| JP-59231017-A | — | — | None | — | — | JP | disclosed |
| US-4525478-A | Certain 4-aryl-1,4-dihydro-3,5-pyridinedicarboxylates having vasodilating and anti-hypertensive properties | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-25 | — | — | US | disclosed |
| JP-S59231017-A | VASODILATOR AND HYPOTENSOR CONTAINING 1,4 - DIHYDROPYRIDINE DERIVATIVE | FUJISAWA PHARMACEUT CO LTD | 1984-12-25 | — | — | JP | disclosed |
| US-4370334-A | VASODILATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-01-25 | — | — | US | disclosed |
| US-4338322-A | 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1982-07-06 | — | — | US | disclosed |
| US-4284634-A | HYPOTENSIVE VASODILATORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-08-18 | — | — | US | disclosed |
| US-4145432-A | 6-ACYLORYALKYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND A METHOD OF EFFECTING VASODILATION THEREWITH | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1979-03-20 | — | — | US | disclosed |