SCHEMBL7380339

SCHEMBL7380339

O=C(O)C1CCCN(c2ccncc2)C1

nearest known ligand 0.59

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
NOTUM Q6P988 13/20 0.59
KDM4E B2RXH2 3/20 0.54
MEN1 O00255 1/20 0.54
ALDH1A1 P00352 1/20 0.54
KMT2A Q03164 1/20 0.54
HSD17B10 Q99714 1/20 0.54
CHKA P35790 1/20 0.50
ITGB3 P05106 1/20 0.49
ITGA2B P08514 1/20 0.49
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2C9 P11712 1/20 0.44
DPP4 P27487 1/20 0.44
DPP8 Q6V1X1 1/20 0.44
DPP9 Q86TI2 1/20 0.44
DPP7 Q9UHL4 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL4681351 0.98 NOTUM (0.58) NOTUMKDM4EMEN1ALDH1A1KMT2A
SCHEMBL8554143 0.86 SMN1; SMN2 (0.56) NOTUMKDM4EALDH1A1HSD17B10CYP3A4
SCHEMBL613112 0.85 NOTUM (0.81) NOTUMKDM4EMEN1ALDH1A1KMT2A
SCHEMBL4961935 0.85 NOTUM (0.81) NOTUMKDM4EMEN1ALDH1A1KMT2A
SCHEMBL26107713 0.84 NOTUM (0.59) NOTUMKDM4EMEN1ALDH1A1KMT2A
SCHEMBL29514498 0.83 NOTUM (0.51) NOTUMHSD17B10CHKAITGB3ITGA2B
SCHEMBL31401390 0.82 KDM4E (0.46) KDM4EMEN1ALDH1A1KMT2ACHKA
SCHEMBL6184503 0.82 LSS (0.55) NOTUMITGB3ITGA2B
SCHEMBL15903929 0.81 NOTUM (0.64) NOTUMKDM4EMEN1ALDH1A1KMT2A
SCHEMBL16695575 0.81 NOTUM (0.82) NOTUM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6294549-B1 COMPOUNDS USEFUL FOR INHIBITING RESTENOSIS, ANGIOGENESIS, ATHEROSCLEROSIS, DIABETIC RETINOPATHY, MACULAR DEGENERATION, INFLAMMATION OR TUMOR GROWTH. MERCK & CO., INC. 2001-09-25 US disclosed
US-5952306-A INHIBITING THE BINDING OF FIBRINOGEN TO BLOOD PLATELETS AND INHIBITING THE AGGREGATION OF BLOOD PLATELETS; INHIBITING OSTEOCLAST CELLULAR ADHESION TO BONE SURFACES MERCK & CO., INC. (US) 1999-09-14 US disclosed
EP-0880511-A4 INTEGRIN RECEPTOR ANTAGONISTS MERCK & CO INC (US) 1999-06-16 EP disclosed
EP-0880511-A1 INTEGRIN RECEPTOR ANTAGONISTS Merck & Co., Inc. (US) 1998-12-02 EP disclosed
WO-1997026250-A1 INTEGRIN RECEPTOR ANTAGONISTS MERCK & CO., INC. (US) 1997-07-24 WO disclosed