Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.48 |
| ▸ | RAB9A | P51151 | 8/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12304173 | 0.82 | NPC1 (0.56) | NPC1RAB9AHDAC3NCOR2MEN1 | |
| SCHEMBL23623799 | 0.81 | NPC1 (0.54) | NPC1RAB9AHDAC3NCOR2MMP2 | |
| SCHEMBL38657612 | 0.78 | NPC1 (0.51) | NPC1RAB9AHDAC3NCOR2MMP2 | |
| SCHEMBL15265396 | 0.77 | NPC1 (0.57) | NPC1RAB9AHDAC3NCOR2 | |
| SCHEMBL7395723 | 0.77 | NPC1 (0.50) | NPC1RAB9AHDAC3NCOR2MEN1 | |
| SCHEMBL7416043 | 0.76 | NPC1 (0.51) | NPC1RAB9AHDAC3NCOR2MMP2 | |
| SCHEMBL4205816 | 0.76 | NPC1 (0.48) | NPC1RAB9AHDAC3NCOR2MMP2 | |
| SCHEMBL11911576 | 0.75 | NPC1 (0.51) | NPC1RAB9AHDAC3NCOR2ALDH1A1 | |
| SCHEMBL906398 | 0.75 | RAB9A (0.62) | NPC1RAB9AHDAC3NCOR2KMT2A | |
| SCHEMBL9068949 | 0.75 | NPC1 (0.48) | NPC1RAB9AHDAC3NCOR2MMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0934267-A1 | $g(a)-AMINO SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 1999-08-11 | — | — | EP | disclosed |
| WO-1998017645-A1 | α-AMINO SULFONYL HYDROXAMIC ACIDS AS MATRIX METALLOPROTEINASE INHIBITORS | PHARMACIA & UPJOHN COMPANY (US) | 1998-04-30 | — | — | WO | disclosed |