Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 8/20 | 0.53 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 8/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 8/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 7/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.53 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.41 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7372496 | 0.91 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7435984 | 0.82 | PDE4A (0.65) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7427542 | 0.82 | PDE3B (0.51) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7376882 | 0.82 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7379032 | 0.80 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7429700 | 0.80 | PDE4A (0.50) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7438382 | 0.79 | PDE3B (0.53) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7381431 | 0.78 | PDE3B (0.57) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7435625 | 0.77 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7431591 | 0.77 | PDE3B (0.58) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0381374-A1 | Phosphodiesterase inhibitors | LES LABORATOIRES BEECHAM S.A. (FR) | 1990-08-08 | — | — | EP | claimed |
| EP-0381374-A1 | Phosphodiesterase inhibitors | LES LABORATOIRES BEECHAM S.A. (FR) | 1990-08-08 | — | — | EP | disclosed |