Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 12/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 12/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.65 |
| ▸ | PDE3B | Q13370 | 14/20 | 0.63 |
| ▸ | PDE3A | Q14432 | 14/20 | 0.63 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | FBP1 | P09467 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7431591 | 0.84 | PDE3B (0.58) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7381431 | 0.84 | PDE3B (0.57) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7381427 | 0.84 | PDE3B (0.57) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7376882 | 0.84 | PDE4A (0.57) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7429294 | 0.84 | PDE3B (0.57) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7380385 | 0.82 | PDE4A (0.53) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7372496 | 0.81 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7428441 | 0.80 | PDE3B (0.53) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7438382 | 0.80 | PDE3B (0.53) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7376614 | 0.80 | PDE3B (0.53) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0303418-A2 | Substituted indolones, useful in the treatment of heart or asthmatic diseases | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1989-02-15 | — | — | EP | claimed |
| US-4933336-A | Thiadiazinone, oxadiazinone and triazinone derivatives, and their use for treating acute or chronic heart disease | LABORATOIRES SOBIO S.A. (FR) | 1990-06-12 | — | — | US | disclosed |
| EP-0303418-A2 | Substituted indolones, useful in the treatment of heart or asthmatic diseases | SMITHKLINE BEECHAM LABORATOIRES PHARMACEUTIQUES (FR) | 1989-02-15 | — | — | EP | disclosed |