Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIF11 | P52732 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | CACNA1F | O60840 | 9/20 | 0.54 |
| ▸ | CACNA1D | Q01668 | 9/20 | 0.54 |
| ▸ | CACNA1S | Q13698 | 9/20 | 0.54 |
| ▸ | CACNA1C | Q13936 | 9/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.54 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11785984 | 0.87 | KDM4E (0.70) | KIF11KDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL7382267 | 0.84 | CACNA1F (0.78) | TSHRCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL17367959 | 0.82 | KDM4E (0.64) | KIF11KDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL7381268 | 0.81 | KIF11 (0.60) | KIF11KDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL11170529 | 0.80 | CACNA1F (0.71) | TSHRCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL11446581 | 0.80 | CACNA1F (0.71) | TSHRCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7373883 | 0.80 | CACNA1F (0.72) | TSHRCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7383740 | 0.80 | KIF11 (0.58) | KIF11KDM4EALDH1A1TSHRSMN1; SMN2 | |
| SCHEMBL7380821 | 0.79 | CACNA1F (0.71) | TSHRCACNA1FCACNA1DCACNA1SCACNA1C | |
| SCHEMBL7382302 | 0.79 | CACNA1F (0.74) | TSHRCACNA1FCACNA1DCACNA1SCACNA1C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4284634-A | HYPOTENSIVE VASODILATORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-08-18 | — | — | US | claimed |
| US-4525478-A | Certain 4-aryl-1,4-dihydro-3,5-pyridinedicarboxylates having vasodilating and anti-hypertensive properties | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-25 | — | — | US | disclosed |
| US-4370334-A | VASODILATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-01-25 | — | — | US | disclosed |
| US-4338322-A | 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1982-07-06 | — | — | US | disclosed |
| US-4284634-A | HYPOTENSIVE VASODILATORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-08-18 | — | — | US | disclosed |
| US-4145432-A | 6-ACYLORYALKYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND A METHOD OF EFFECTING VASODILATION THEREWITH | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1979-03-20 | — | — | US | disclosed |