Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 8/20 | 0.64 |
| ▸ | C1S | P09871 | 3/20 | 0.48 |
| ▸ | F9 | P00740 | 3/20 | 0.48 |
| ▸ | F10 | P00742 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | CTSV | O60911 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6920484 | 0.95 | PLAU (0.69) | PLAUC1SF9F10KMT2A | |
| Hydrochloric Acid SCHEMBL6920775 | 0.94 | PLAU (0.68) | PLAUC1SF9F10KMT2A | |
| SCHEMBL7374623 | 0.94 | PLAU (0.57) | PLAUC1SF9F10KMT2A | |
| SCHEMBL6926600 | 0.86 | PLAU (0.50) | PLAUC1S | |
| Hydrochloric Acid SCHEMBL6925281 | 0.85 | PLAU (0.49) | PLAUC1S | |
| SCHEMBL6924736 | 0.85 | PLAU (0.57) | PLAUC1SF9F10SIRT2 | |
| SCHEMBL6921915 | 0.84 | PLAU (0.53) | PLAUKMT2ASIRT2MEN1NPC1 | |
| SCHEMBL7996791 | 0.82 | PLAU (0.53) | PLAUC1S | |
| SCHEMBL6927242 | 0.81 | PLAU (0.66) | PLAUC1S | |
| SCHEMBL6921142 | 0.79 | PLAU (0.63) | PLAUC1S |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1150979-A1 | HETEROARYL AMIDINES, METHYLAMIDINES AND GUANIDINES AS PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2001-11-07 | — | — | EP | claimed |
| WO-2000047578-A1 | HETEROARYL AMIDINES, METHYLAMIDINES AND GUANIDINES AS PROTEASE INHIBITORS | 3-DIMENSIONAL PHARMACEUTICALS, INC. (US) | 2000-08-17 | — | — | WO | claimed |