Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.43 |
| ▸ | F12 | P00748 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | LGMN | Q99538 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15238296 | 0.82 | ALDH1A1 (0.57) | POLBALDH1A1F12MAPTKMT2A | |
| SCHEMBL6074502 | 0.79 | MAPT (0.54) | POLBALDH1A1F12MAPTKMT2A | |
| SCHEMBL7382087 | 0.78 | POLB (0.48) | POLBALDH1A1F12MAPTKMT2A | |
| SCHEMBL6134378 | 0.77 | ALDH1A1 (0.51) | POLBALDH1A1F12MAPTKMT2A | |
| SCHEMBL1663834 | 0.76 | KDM4E (0.53) | POLBALDH1A1F12MAPTKMT2A | |
| SCHEMBL6134959 | 0.74 | POLB (0.50) | POLBALDH1A1F12MAPTLGMN | |
| SCHEMBL1743474 | 0.73 | MEN1 (0.55) | POLBALDH1A1KMT2ASMN1; SMN2HPGD | |
| Hydrochloric Acid SCHEMBL6132612 | 0.73 | KDM4E (0.50) | POLBALDH1A1F12LGMNNPC1 | |
| SCHEMBL6132298 | 0.72 | MEN1 (0.54) | POLBALDH1A1MAPTKMT2ALMNA | |
| SCHEMBL6132593 | 0.72 | GFER (0.59) | ALDH1A1MAPTKMT2ALGMNLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4661496-A | Cardiotonic and antihypertensive 2,4-dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones | WARNER-LAMBERT COMPANY (US) | 1987-04-28 | — | — | US | disclosed |
| US-4550119-A | 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones | WARNER-LAMBERT COMPANY (US) | 1985-10-29 | — | — | US | disclosed |
| US-4526982-A | 2,4-Dihydro-5-[(substituted)phenyl]-4,4-disubstituted-3H-pyrazol-3-ones | WARNER-LAMBERT COMPANY, A CORP. OF DEL. | 1985-07-02 | — | — | US | disclosed |
| EP-0126651-A2 | 2,4-Dihydro-5-((substituted)phenyl)-4,4-disubstituted-3H-pyrazol-3-ones, 2,4-dihydro-5-((substituted)phenyl)-4, 4-disubstituted-3H-pyrazol-3-thiones, and a process for producing the same | WARNER-LAMBERT COMPANY (US) | 1984-11-28 | — | — | EP | disclosed |