Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7380940 | 0.86 | NR1I2 (0.55) | NR1I2GAAKDM4EMAPTTSHR | |
| SCHEMBL7379344 | 0.84 | NR1I2 (0.47) | NR1I2GAAKDM4EMAPTTSHR | |
| SCHEMBL7377766 | 0.84 | NR1I2 (0.47) | NR1I2GAAKDM4EMAPTTSHR | |
| SCHEMBL7374071 | 0.83 | NR1I2 (0.46) | NR1I2GAAKDM4EMAPTTSHR | |
| SCHEMBL7382176 | 0.81 | TSHR (0.51) | NR1I2GAAKDM4EMAPTTSHR | |
| SCHEMBL7379284 | 0.80 | NR1I2 (0.47) | NR1I2KDM4EMAPTTSHRTP53 | |
| SCHEMBL7379723 | 0.80 | KDM4E (0.45) | NR1I2GAAKDM4EMAPTTSHR | |
| SCHEMBL7381416 | 0.79 | KDM4E (0.49) | NR1I2GAAKDM4EMAPTTSHR | |
| SCHEMBL11189265 | 0.79 | NR1I2 (0.48) | NR1I2KDM4EMAPTTSHRTP53 | |
| SCHEMBL7385215 | 0.78 | ADORA3 (0.57) | KDM4EMAPTTSHRHTTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4525478-A | Certain 4-aryl-1,4-dihydro-3,5-pyridinedicarboxylates having vasodilating and anti-hypertensive properties | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-25 | — | — | US | disclosed |
| US-4370334-A | VASODILATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-01-25 | — | — | US | disclosed |
| US-4338322-A | 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1982-07-06 | — | — | US | disclosed |
| US-4284634-A | HYPOTENSIVE VASODILATORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-08-18 | — | — | US | disclosed |