SCHEMBL7380746

SCHEMBL7380746

CCOC(=O)/C(=C\c1nc2cc(C#N)ccc2[nH]1)c1ccc(O[C@H]2CCN(C(=O)OC(C)(C)C)C2)cc1

nearest known ligand 0.49

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 8/20 0.49
CHEK2 O96017 5/20 0.46
ALK Q9UM73 1/20 0.42
CETP P11597 2/20 0.40
PIK3CD O00329 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7380750 1.00 GPR119 (0.49) GPR119CHEK2ALKCETPPIK3CD
SCHEMBL7380752 0.94 CHEK2 (0.51) GPR119CHEK2ALKCETP
SCHEMBL7388215 0.85 GPR119 (0.51) GPR119CHEK2ALKCETP
SCHEMBL7388213 0.85 GPR119 (0.51) GPR119CHEK2ALKCETP
SCHEMBL7390133 0.84 GPR119 (0.50) GPR119CHEK2ALKCETP
SCHEMBL7387571 0.84 GPR119 (0.50) GPR119CHEK2ALKCETP
SCHEMBL7387569 0.84 GPR119 (0.50) GPR119CHEK2ALKCETP
SCHEMBL7390135 0.84 GPR119 (0.50) GPR119CHEK2ALKCETP
SCHEMBL7387574 0.82 GPR119 (0.49) GPR119CHEK2ALKCETP
SCHEMBL7390222 0.80 GPR119 (0.49) GPR119CHEK2ALKCETP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5620991-A ANTICOAGULANTS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1997-04-15 US disclosed
US-5576343-A ANTICOAGULANTS; BLOOD-COAGULATION FACTOR X INHIBITORS DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1996-11-19 US disclosed
EP-0540051-B1 Aromatic amidine derivatives and salts thereof DAIICHI SEIYAKU CO (JP) 1996-04-03 EP disclosed
EP-0540051-A1 Aromatic amidine derivatives and salts thereof DAIICHI PHARMACEUTICAL CO., LTD. (JP) 1993-05-05 EP disclosed