Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A2 | P31213 | 3/20 | 0.58 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.58 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7386216 | 1.00 | SRD5A2 (0.58) | SRD5A2SRD5A1ARSERPINA6 | |
| SCHEMBL8016958 | 0.91 | SRD5A2 (0.58) | SRD5A2SRD5A1AR | |
| SCHEMBL8016963 | 0.91 | SRD5A2 (0.58) | SRD5A2SRD5A1AR | |
| SCHEMBL8016669 | 0.91 | SRD5A2 (0.58) | SRD5A2SRD5A1AR | |
| SCHEMBL8478274 | 0.88 | SRD5A2 (0.55) | SRD5A2SRD5A1AR | |
| SCHEMBL8478279 | 0.88 | SRD5A2 (0.55) | SRD5A2SRD5A1AR | |
| SCHEMBL28559933 | 0.82 | SRD5A2 (0.73) | SRD5A2SRD5A1AR | |
| SCHEMBL14360068 | 0.82 | SRD5A2 (0.73) | SRD5A2SRD5A1AR | |
| SCHEMBL14477862 | 0.82 | SRD5A2 (0.73) | SRD5A2SRD5A1AR | |
| SCHEMBL8892299 | 0.82 | SRD5A1 (0.75) | SRD5A2SRD5A1AR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0862556-B1 | 17-ALKYL-7-SUBSTITUTED-4-AZA STEROID DERIVATIVES | MERCK & CO INC (US) | 2001-09-05 | — | — | EP | disclosed |
| US-5872126-A | ENZYME INHIBITORS FOR TREATMENT OF PREMATURE LABOR | MERCK & CO., INC. (US) | 1999-02-16 | — | — | US | disclosed |
| EP-0862556-A4 | 17-ALKYL-7-SUBSTITUTED-4-AZA STEROID DERIVATIVES | MERCK & CO INC (US) | 1999-02-03 | — | — | EP | disclosed |
| WO-1998041211-A1 | METHODS AND COMPOSITIONS FOR TREATING POLYCYSTIC OVARY SYNDROME | MERCK & CO., INC. (US) | 1998-09-24 | — | — | WO | disclosed |
| EP-0862556-A1 | 17-ALKYL-7-SUBSTITUTED-4-AZA STEROID DERIVATIVES | Merck & Co., Inc. (US) | 1998-09-09 | — | — | EP | disclosed |
| WO-1998025622-A1 | METHODS AND COMPOSITIONS FOR PREVENTING AND TREATING BONE LOSS | MERCK & CO., INC. (US) | 1998-06-18 | — | — | WO | disclosed |
| US-5763361-A | 17-alkyl-7-substituted-4-aza steroid derivatives as 5-α-reductase inhibitors | MERCK & CO., INC. (US) | 1998-06-09 | — | — | US | disclosed |
| EP-0711164-B1 | 4-AZA-PREGNANE 5-ALPHA-REDUCTASE ISOZYME 1 INHIBITORS | MERCK & CO INC (US) | 1997-09-17 | — | — | EP | disclosed |
| US-5658922-A | 4-aza-pregnane 5α-reductase isozyme 1 inhibitors | MERCK & CO., INC. (US) | 1997-08-19 | — | — | US | disclosed |
| WO-1997015558-A1 | 17-ALKYL-7-SUBSTITUTED-4-AZA STEROID DERIVATIVES | MERCK & CO., INC. (US) | 1997-05-01 | — | — | WO | disclosed |
| EP-0711164-A4 | 4-AZA-PREGNANE 5-ALPHA-REDUCTASE ISOZYME 1 INHIBITORS | MERCK & CO INC (US) | 1996-07-03 | — | — | EP | disclosed |
| EP-0711164-A1 | 4-AZA-PREGNANE 5-ALPHA-REDUCTASE ISOZYME 1 INHIBITORS | MERCK & CO INC (US) | 1996-05-15 | — | — | EP | disclosed |
| WO-1995000147-A1 | 4-AZA-PREGNANE 5α-REDUCTASE ISOZYME 1 INHIBITORS | MERCK & CO., INC. (US) | 1995-01-05 | — | — | WO | disclosed |