Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15905970 | 0.89 | MMP8 (0.56) | MMP8ALDH1A1TSHRLMNARECQL | |
| SCHEMBL28737716 | 0.83 | MMP8 (0.60) | MMP8ALDH1A1TSHRLMNAMAPT | |
| SCHEMBL7362869 | 0.82 | MMP8 (0.59) | MMP8ALDH1A1TSHRLMNAMAPT | |
| SCHEMBL2370973 | 0.82 | MMP8 (0.59) | MMP8ALDH1A1TSHRKDM4ELMNA | |
| SCHEMBL28753087 | 0.81 | MMP8 (0.57) | MMP8ALDH1A1KDM4ELMNAMAPT | |
| SCHEMBL458395 | 0.81 | MMP8 (0.57) | MMP8ALDH1A1TSHRLMNARECQL | |
| SCHEMBL8710582 | 0.80 | MMP8 (0.79) | MMP8ALDH1A1TSHRLMNAHSD17B10 | |
| SCHEMBL24733330 | 0.79 | MMP8 (0.56) | MMP8ALDH1A1TSHRKDM4ELMNA | |
| SCHEMBL7383887 | 0.78 | EPHX2 (0.45) | TSHRKDM4EMAPTEPHX2NR1H4 | |
| SCHEMBL12142745 | 0.78 | MMP8 (0.55) | MMP8ALDH1A1TSHRLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5208240-A | Alzeheimer's, cardiovascular, respiratory | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0503563-A2 | Novel 8-substituted purines as selective adenosine receptor agents | MERRELL PHARMACEUTICALS INC. (US) | 1992-09-16 | — | — | EP | disclosed |